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shk1 PAK-like kinase Shk1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539997, updated on 18-Sep-2024

Summary

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Official Symbol
shk1
Official Full Name
PAK-like kinase Shk1
Primary source
PomBase:SPBC1604.14c
Locus tag
SPOM_SPBC1604.14C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
orb2; pak1
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Genomic context

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See shk1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (3904616..3907593)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene G-patch type RNA-binding protein Neighboring gene pig-T family GPI synthesis protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene mitochondrial 54S ribosomal protein bL32m

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arp2/3-dependent endocytosis ensures Cdc42 oscillations by removing Pak1-mediated negative feedback. Harrell MA, et al. J Cell Biol, 2024 Sep 2. PMID 39012625, Free PMC Article
  2. Fission yeast Pak1 phosphorylates anillin-like Mid1 for spatial control of cytokinesis. Magliozzi JO, et al. J Cell Biol, 2020 Aug 3. PMID 32421151, Free PMC Article
  3. Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating. Ottilie S, et al. EMBO J, 1995 Dec 1. PMID 8846783, Free PMC Article
  4. Fission yeast orb6, a ser/thr protein kinase related to mammalian rho kinase and myotonic dystrophy kinase, is required for maintenance of cell polarity and coordinates cell morphogenesis with the cell cycle. Verde F, et al. Proc Natl Acad Sci U S A, 1998 Jun 23. PMID 9636183, Free PMC Article
  5. Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe. Marcus S, et al. Proc Natl Acad Sci U S A, 1995 Jun 20. PMID 7597098, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pak1 kinase controls cell shape through ribonucleoprotein granules.
    Title: Pak1 kinase controls cell shape through ribonucleoprotein granules.
  2. Fission yeast Pak1 phosphorylates anillin-like Mid1 for spatial control of cytokinesis.
    Title: Fission yeast Pak1 phosphorylates anillin-like Mid1 for spatial control of cytokinesis.
  3. Phosphorylation of the Myo1 TEDS site by Pak1 and Nak1 plays a crucial role in regulating Myo1 localisation and cellular function.
    Title: Ste20-kinase-dependent TEDS-site phosphorylation modulates the dynamic localisation and endocytic function of the fission yeast class I myosin, Myo1.
  4. Schizosaccharomyces pombe Pak-related protein, Pak1p/Orb2p, phosphorylates myosin II regulatory light chain (Rlc1p) to inhibit cytokinesis.
    Title: Schizosaccharomyces pombe Pak-related protein, Pak1p/Orb2p, phosphorylates myosin regulatory light chain to inhibit cytokinesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of mitotic actomyosin contractile ring contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endocytosis EXP
Inferred from Experiment
more info
 PubMed 
involved_in positive regulation of establishment of bipolar cell polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of maintenance of bipolar cell polarity regulating cell shape EXP
Inferred from Experiment
more info
 PubMed 
involved_in positive regulation of mitotic cytokinesis, division site positioning EXP
Inferred from Experiment
more info
 PubMed 
involved_in positive regulation of pheromone response MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of microtubule cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of Cdc42 GTPase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cell cortex of cell tip EXP
Inferred from Experiment
more info
 PubMed 
is_active_in cell division site HDA PubMed 
is_active_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell tip HDA PubMed 
is_active_in cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in mitotic actomyosin contractile ring EXP
Inferred from Experiment
more info
 PubMed 
is_active_in mitotic actomyosin contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic actomyosin contractile ring, intermediate layer IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
PAK-like kinase Shk1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    3904616..3907593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022547.3 → NP_596626.1  PAK-like kinase Shk1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596626.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P50527
    Conserved Domains (3) summary
    smart00220
    Location:391 → 637
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06614
    Location:385 → 638
    STKc_PAK; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase
    pfam00786
    Location:146 → 200
    PBD; P21-Rho-binding domain
Nucleotide Protein
Heading Accession and Version

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