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pmp1 dual-specificity MAP kinase phosphatase Pmp1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540019, updated on 18-Sep-2024

Summary

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Official Symbol
pmp1
Official Full Name
dual-specificity MAP kinase phosphatase Pmp1
Primary source
PomBase:SPBC1685.01
Locus tag
SPOM_SPBC1685.01
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
dsp1
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Genomic context

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See pmp1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (496533..499230)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene gamma tubulin complex linker Mto2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 40S ribosomal protein eS12 Neighboring gene ncRNA Neighboring gene signal peptidase subunit Sec11 Neighboring gene ncRNA Neighboring gene V-type ATPase V0 subunit e

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In vitro assay of the interaction between Rnc1 protein and Pmp1 mRNA by affinity capillary electrophoresis with a carboxylated capillary. Taga A, et al. J Pharm Biomed Anal, 2010 Dec 15. PMID 20692117
  2. The role of the regulatory subunit of fission yeast calcineurin for in vivo activity and its relevance to FK506 sensitivity. Sio SO, et al. J Biol Chem, 2005 Apr 1. PMID 15657058
  3. Stress-induced response, localization, and regulation of the Pmk1 cell integrity pathway in Schizosaccharomyces pombe. Madrid M, et al. J Biol Chem, 2006 Jan 27. PMID 16291757
  4. pmp1+, a suppressor of calcineurin deficiency, encodes a novel MAP kinase phosphatase in fission yeast. Sugiura R, et al. EMBO J, 1998 Jan 2. PMID 9427748, Free PMC Article
  5. Feedback regulation of MAPK signalling by an RNA-binding protein. Sugiura R, et al. Nature, 2003 Aug 21. PMID 12931193

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate the role of the IYT motif of dual-specificity MAPK phosphatases Pmp1 in binding and trapping mitogen-activated protein kinase Pmk1.
    Title: A conserved non-canonical docking mechanism regulates the binding of dual specificity phosphatases to cell integrity mitogen-activated protein kinases (MAPKs) in budding and fission yeasts.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables MAP kinase tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell integrity MAPK cascade EXP
Inferred from Experiment
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dual-specificity MAP kinase phosphatase Pmp1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    496533..499230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021111.3 → NP_595205.1  dual-specificity MAP kinase phosphatase Pmp1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595205.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13453
    Conserved Domains (2) summary
    COG2453
    Location:35 → 227
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    cd00127
    Location:61 → 209
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
Nucleotide Protein
Heading Accession and Version

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Research Materials