rep2 transcriptional activator MBF subunit Rep2 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

Official Symbol: rep2
Official Full Name: transcriptional activator MBF subunit Rep2
Primary source: PomBase:SPBC2F12.11c
Locus tag: SPOM_SPBC2F12.11C
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Chromosome II - NC_003423.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Gcn5-mediated acetylation at MBF-regulated promoters induces the G1-S transcriptional wave.
Title: Gcn5-mediated acetylation at MBF-regulated promoters induces the G1/S transcriptional wave.
Study found the mRNA for rep2, an important factor for transcription of vegetative S-phase transcripts rather than meiotic transcripts.
Title: mmi1 and rep2 mRNAs are novel RNA targets of the Mei2 RNA-binding protein during early meiosis in Schizosaccharomyces pombe.
MBF activator Rep2 plays a role in mediating the cell cycle-specific transcription through the recruitment of RNAP-II to the MBF-bound G(1)/S-phase genes.
Title: Deconvolution of chromatin immunoprecipitation-microarray (ChIP-chip) analysis of MBF occupancies reveals the temporal recruitment of Rep2 at the MBF target genes.
Cds1-dependent stabilization of Rep2 is achieved through the inhibition/phosphorylation of APC/C-Ste9 at the onset of S-phase arrest.
Title: A Cds1-mediated checkpoint protects the MBF activator Rep2 from ubiquitination by anaphase-promoting complex/cyclosome-Ste9 at S-phase arrest in fission yeast.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables SAGA complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed