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rec8 meiotic cohesin complex kleisin subunit Rec8 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540458, updated on 18-Sep-2024

Summary

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Official Symbol
rec8
Official Full Name
meiotic cohesin complex kleisin subunit Rec8
Primary source
PomBase:SPBC29A10.14
Locus tag
SPOM_SPBC29A10.14
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See rec8 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003423.3 (2568938..2570993)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene F0-ATPase subunit D Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene origin recognition complex subunit Orc1 Neighboring gene ncRNA Neighboring gene Ragulator-Rag complex subunit Lam1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Kinetochore geometry defined by cohesin within the centromere]. Sakuno T, et al. Tanpakushitsu Kakusan Koso, 2009 Nov. PMID 19894585
  2. Rec8 Cohesin-mediated Axis-loop chromatin architecture is required for meiotic recombination. Sakuno T, et al. Nucleic Acids Res, 2022 Apr 22. PMID 35333350, Free PMC Article
  3. Cohesin Rec8 is required for reductional chromosome segregation at meiosis. Watanabe Y, et al. Nature, 1999 Jul 29. PMID 10440376
  4. Distinct cohesin complexes organize meiotic chromosome domains. Kitajima TS, et al. Science, 2003 May 16. PMID 12750522
  5. Meiotic cohesins modulate chromosome compaction during meiotic prophase in fission yeast. Ding DQ, et al. J Cell Biol, 2006 Aug 14. PMID 16893973, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rec8 Cohesin-mediated Axis-loop chromatin architecture is required for meiotic recombination.
    Title: Rec8 Cohesin-mediated Axis-loop chromatin architecture is required for meiotic recombination.
  2. Centromeres are dismantled by foundational meiotic proteins Spo11 and Rec8.
    Title: Centromeres are dismantled by foundational meiotic proteins Spo11 and Rec8.
  3. Rec8 and Pds5 play an essential role in building a platform to support the chromosome architecture necessary for the spatial alignment of homologous chromosomes.
    Title: Meiotic cohesin-based chromosome structure is essential for homologous chromosome pairing in Schizosaccharomyces pombe.
  4. balance between Rec8 phosphorylation and its dephosphorylation by Sgo1-PP2A regulates the step-wise loss of chromosomal cohesion in meiosis
    Title: Shugoshin-PP2A counteracts casein-kinase-1-dependent cleavage of Rec8 by separase.
  5. Cohesin within the centromere regulates kinetochore geometry. (review)
    Title: [Kinetochore geometry defined by cohesin within the centromere].
  6. Meiotic prophase chromosomes are organized as chromatin loops emanating from a Rec8-containing axis: the absence of Rec8 disrupts the axis, resulting in disorganized chromosomes.
    Title: Meiotic cohesins modulate chromosome compaction during meiotic prophase in fission yeast.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables topological DNA co-entrapment activity EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homologous chromosome orientation in meiotic metaphase I IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic centromeric cohesion protection in anaphase I EXP
Inferred from Experiment
more info
 PubMed 
involved_in meiotic centromeric cohesion protection in anaphase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic sister chromatid cohesion involved in meiosis I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle attachment to meiosis I kinetochore EXP
Inferred from Experiment
more info
 PubMed 
involved_in spindle attachment to meiosis I kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cohesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of meiotic cohesin complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in meiotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in pericentric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
meiotic cohesin complex kleisin subunit Rec8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    2568938..2570993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021970.3 → NP_596059.1  meiotic cohesin complex kleisin subunit Rec8 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596059.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O60051, P36626
    Conserved Domains (2) summary
    pfam04824
    Location:503 → 557
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
    pfam04825
    Location:1 → 93
    Rad21_Rec8_N; N terminus of Rad21 / Rec8 like protein
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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