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nrl1 NRDE-2 family protein [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540691, updated on 18-Sep-2024

Summary

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Official Symbol
nrl1
Official Full Name
NRDE-2 family protein
Primary source
PomBase:SPBC20F10.05
Locus tag
SPOM_SPBC20F10.05
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See nrl1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003423.3 (3290886..3294106)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene non-structural maintenance of chromosome element 4 Neighboring gene mitotic spindle checkpoint protein Mad2 Neighboring gene ncRNA Neighboring gene sterol transfer protein Ltc1 Neighboring gene RNA polymerase II nuclear import protein Rtp1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of Nrl1 Domains Responsible for Interactions with RNA-Processing Factors and Regulation of Nrl1 Function by Phosphorylation. Mikolaskova B, et al. Int J Mol Sci, 2021 Jun 29. PMID 34209806, Free PMC Article
  2. Conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing. Chalamcharla VR, et al. Proc Natl Acad Sci U S A, 2015 Dec 22. PMID 26631744, Free PMC Article
  3. The fission yeast MTREC complex targets CUTs and unspliced pre-mRNAs to the nuclear exosome. Zhou Y, et al. Nat Commun, 2015 May 20. PMID 25989903, Free PMC Article
  4. The spliceosome-associated protein Nrl1 suppresses homologous recombination-dependent R-loop formation in fission yeast. Aronica L, et al. Nucleic Acids Res, 2016 Feb 29. PMID 26682798, Free PMC Article
  5. Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance. Lee NN, et al. Cell, 2013 Nov 21. PMID 24210919, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of Nrl1 Domains Responsible for Interactions with RNA-Processing Factors and Regulation of Nrl1 Function by Phosphorylation.
    Title: Identification of Nrl1 Domains Responsible for Interactions with RNA-Processing Factors and Regulation of Nrl1 Function by Phosphorylation.
  2. we establish roles for the evolutionarily conserved Nrl1 protein in pre-mRNA splicing regulation, R-loop suppression and in maintaining genome stability.
    Title: The spliceosome-associated protein Nrl1 suppresses homologous recombination-dependent R-loop formation in fission yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of RNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear mRNA surveillance of spliceosomal pre-mRNA splicing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulatory ncRNA-mediated heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in siRNA-mediated facultative heterochromatin formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus HDA PubMed 
part_of spliceosomal complex EXP
Inferred from Experiment
more info
 PubMed 

General protein information

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Preferred Names
NRDE-2 family protein
NP_596369.1
  • RNAi-mediated silencing protein, human NRDE2 ortholog Nrl1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    3290886..3294106
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022290.3 → NP_596369.1  NRDE-2 family protein [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596369.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O42975
    Conserved Domains (1) summary
    pfam08424
    Location:167 → 476
    NRDE-2; NRDE-2, necessary for RNA interference
Nucleotide Protein
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