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pek1 MAP kinase kinase Pek1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540919, updated on 18-Sep-2024

Summary

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Official Symbol
pek1
Official Full Name
MAP kinase kinase Pek1
Primary source
PomBase:SPBC543.07
Locus tag
SPOM_SPBC543.07
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
mkk1; skh1
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Genomic context

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See pek1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (4312443..4314140)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ATP-dependent RNA helicase Dbp8 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CoA pyrophosphatase (FIT) family lipid storage protein Neighboring gene ncRNA Neighboring gene m-AAA protease Yta12

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Skh1, the MEK component of the mkh1 signaling pathway in Schizosaccharomyces pombe. Loewith R, et al. J Cell Sci, 2000 Jan. PMID 10591634
  2. Distinct biological activity of threonine monophosphorylated MAPK isoforms during the stress response in fission yeast. Vázquez B, et al. Cell Signal, 2015 Dec. PMID 26432170
  3. Stress-induced response, localization, and regulation of the Pmk1 cell integrity pathway in Schizosaccharomyces pombe. Madrid M, et al. J Biol Chem, 2006 Jan 27. PMID 16291757
  4. The MAPK kinase Pek1 acts as a phosphorylation-dependent molecular switch. Sugiura R, et al. Nature, 1999 Jun 3. PMID 10365961
  5. Feedback regulation of MAPK signalling by an RNA-binding protein. Sugiura R, et al. Nature, 2003 Aug 21. PMID 12931193

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell integrity MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell integrity MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell wall organization or biogenesis EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of fungal-type cell wall organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in division septum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
MAP kinase kinase Pek1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    4312443..4314140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023815.3 → NP_596795.1  MAP kinase kinase Pek1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596795.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9UUK6, Q9Y884
    Conserved Domains (2) summary
    cd06621
    Location:77 → 361
    PKc_Pek1_like; Catalytic domain of fungal Pek1-like dual-specificity Mitogen-Activated Protein Kinase Kinases
    pfam00069
    Location:85 → 343
    Pkinase; Protein kinase domain
Nucleotide Protein
Heading Accession and Version

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