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spt16 histone H2A-H2B chaperone, FACT complex subunit Spt16 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541355, updated on 18-Sep-2024

Summary

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Official Symbol
spt16
Official Full Name
histone H2A-H2B chaperone, FACT complex subunit Spt16
Primary source
PomBase:SPBP8B7.19
Locus tag
SPOM_SPBP8B7.19
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See spt16 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (3671280..3674622)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene phosphomethylpyrimidine kinase Thi201 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RNA methyltransferase Nop2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ubiquitin hydrolase Ubp3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The chromatin-remodeling factor FACT contributes to centromeric heterochromatin independently of RNAi. Lejeune E, et al. Curr Biol, 2007 Jul 17. PMID 17614284, Free PMC Article
  2. The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions. Murawska M, et al. Mol Cell, 2020 Feb 6. PMID 31837996, Free PMC Article
  3. The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states. Murawska M, et al. Cell Rep, 2021 Nov 2. PMID 34731638, Free PMC Article
  4. Factors that promote H3 chromatin integrity during transcription prevent promiscuous deposition of CENP-A(Cnp1) in fission yeast. Choi ES, et al. PLoS Genet, 2012 Sep. PMID 23028377, Free PMC Article
  5. Abo1, a conserved bromodomain AAA-ATPase, maintains global nucleosome occupancy and organisation. Gal C, et al. EMBO Rep, 2016 Jan. PMID 26582768, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
contributes_to H2A-H2B histone complex chaperone activity EXP
Inferred from Experiment
more info
 PubMed 
enables H2A-H2B histone complex chaperone activity EXP
Inferred from Experiment
more info
 PubMed 
enables H2A-H2B histone complex chaperone activity IC
Inferred by Curator
more info
  
enables histone chaperone activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication-dependent chromatin assembly IC
Inferred by Curator
more info
  
involved_in chromatin organization EXP
Inferred from Experiment
more info
 PubMed 
involved_in constitutive heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription elongation-coupled chromatin remodeling IC
Inferred by Curator
more info
  
Component Evidence Code Pubs
part_of FACT complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of FACT complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in euchromatin EXP
Inferred from Experiment
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histone H2A-H2B chaperone, FACT complex subunit Spt16

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    3671280..3674622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022447.3 → NP_596526.1  histone H2A-H2B chaperone, FACT complex subunit Spt16 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596526.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O94267
    Conserved Domains (5) summary
    COG5406
    Location:1 → 1018
    COG5406; Nucleosome binding factor SPN, SPT16 subunit [Transcription, Replication, recombination and repair, Chromatin structure and dynamics]
    cd01091
    Location:181 → 427
    CDC68-like; Related to aminopeptidase P and aminopeptidase M, a member of this domain family is present in cell division control protein 68, a transcription factor.
    pfam08512
    Location:815 → 896
    Rtt106; Histone chaperone Rttp106-like
    pfam08644
    Location:545 → 690
    SPT16; FACT complex subunit (SPT16/CDC68)
    pfam14826
    Location:6 → 168
    FACT-Spt16_Nlob; FACT complex subunit SPT16 N-terminal lobe domain
Nucleotide Protein
Heading Accession and Version

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