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plc1 phosphoinositide phospholipase C Plc1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541439, updated on 14-Nov-2024

Summary

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Official Symbol
plc1
Official Full Name
phosphoinositide phospholipase C Plc1
Primary source
PomBase:SPAC22F8.11
Locus tag
SPOM_SPAC22F8.11
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See plc1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (4807571..4811555)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene putative U2 snRNP-associated protein Sap145 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene histone H2B-K119 ubiquitin ligase complex (HULC) subunit Shf1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CCR4-Not complex subunit Caf16

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning of the plc1+ gene of Schizosaccharomyces pombe, which encodes a putative phosphoinositide-specific phospholipase C. Andoh T, et al. Yeast, 1995 Feb. PMID 7732727
  2. Phosphoinositide-specific phospholipase C forms a complex with 14-3-3 proteins and is involved in expression of UV resistance in fission yeast. Andoh T, et al. Mol Gen Genet, 1998 Apr. PMID 9613582
  3. Phosphatidylinositol-4-phosphate 5-kinase regulates fission yeast cell integrity through a phospholipase C-mediated protein kinase C-independent pathway. Deng L, et al. J Biol Chem, 2005 Jul 29. PMID 15923187
  4. Posttranslational Arginylation Enzyme Arginyltransferase1 Shows Genetic Interactions With Specific Cellular Pathways in vivo. Wiley DJ, et al. Front Physiol, 2020. PMID 32435206, Free PMC Article
  5. Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Rallis C, et al. Sci Rep, 2017 Mar 10. PMID 28281664, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Its3 PIP5K regulates cell integrity through a Plc1-mediated PKC-independent pathway, in addition to the Rho/PKC pathway
    Title: Phosphatidylinositol-4-phosphate 5-kinase regulates fission yeast cell integrity through a phospholipase C-mediated protein kinase C-independent pathway.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables calcium ion binding ISM
Inferred from Sequence Model
more info
  
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phospholipase C activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in inositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm HDA PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
phosphoinositide phospholipase C Plc1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    4807571..4811555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020162.3 → NP_594734.1  phosphoinositide phospholipase C Plc1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594734.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P40977
    Conserved Domains (7) summary
    cd00275
    Location:767 → 897
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08598
    Location:441 → 737
    PI-PLC1c_yeast; Catalytic domain of putative yeast phosphatidylinositide-specific phospholipases C
    PLN02228
    Location:367 → 883
    PLN02228; Phosphoinositide phospholipase C
    cd00051
    Location:303 → 360
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd13360
    Location:165 → 277
    PH_PLC_fungal; Fungal Phospholipase C (PLC) pleckstrin homology (PH) domain
    pfam09279
    Location:367 → 438
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:303 → 359
    EF-hand_7; EF-hand domain pair
Nucleotide Protein
Heading Accession and Version

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