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isu1 Fe-sulfur cluster assembly protein Isu1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541513, updated on 18-Sep-2024

Summary

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Official Symbol
isu1
Official Full Name
Fe-sulfur cluster assembly protein Isu1
Primary source
PomBase:SPAC227.13c
Locus tag
SPOM_SPAC227.13C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See isu1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (517416..518951, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene folylpolyglutamate synthase Neighboring gene prefoldin subunit 2 Neighboring gene putative misfolded glycoprotein sensor Yos9 Neighboring gene Prp4 family U4/U5/U6 small nuclear ribonucleoprotein complex subunit Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uridine kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of an iron-sulfur cluster assembly protein (ISU1) from Schizosaccharomyces pombe. Wu G, et al. Biochemistry, 2002 Apr 16. PMID 11939799
  2. Iron-sulfur cluster biosynthesis. Kinetic analysis of [2Fe-2S] cluster transfer from holo ISU to apo Fd: role of redox chemistry and a conserved aspartate. Wu SP, et al. Biochemistry, 2002 Jul 16. PMID 12102630
  3. Iron-Sulfur Cluster Biogenesis Chaperones: Evidence for Emergence of Mutational Robustness of a Highly Specific Protein-Protein Interaction. Delewski W, et al. Mol Biol Evol, 2016 Mar. PMID 26545917, Free PMC Article
  4. Biogenesis of Iron-Sulfur Clusters and Their Role in DNA Metabolism. Shi R, et al. Front Cell Dev Biol, 2021. PMID 34660592, Free PMC Article
  5. Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways. Das J, et al. Sci Signal, 2013 May 21. PMID 23695164, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2 iron, 2 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables iron-sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron-sulfur cluster carrier activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in [2Fe-2S] cluster assembly EXP
Inferred from Experiment
more info
 PubMed 
involved_in [2Fe-2S] cluster assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular iron ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron-sulfur cluster assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial [2Fe-2S] assembly complex TAS
Traceable Author Statement
more info
 PubMed 
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
Fe-sulfur cluster assembly protein Isu1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    517416..518951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018367.3 → NP_592967.1  Fe-sulfur cluster assembly protein Isu1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_592967.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9UTC6
    Conserved Domains (1) summary
    TIGR01999
    Location:54 → 177
    iscU; FeS cluster assembly scaffold IscU
Nucleotide Protein
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