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fhl1 DNA-binding forkhead transcription factor for ribosomal proteins Fhl1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541552, updated on 18-Sep-2024

Summary

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Official Symbol
fhl1
Official Full Name
DNA-binding forkhead transcription factor for ribosomal proteins Fhl1
Primary source
PomBase:SPAC1142.08
Locus tag
SPOM_SPAC1142.08
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
SPAC8C9.01
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Genomic context

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See fhl1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (3639812..3642338)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene GET complex ATPase subunit Get3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ESCRT III complex subunit Vps32 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene cAMP-dependent protein kinase regulatory subunit Cgs1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Product of the Fission Yeast fhl1 Gene Binds to the HomolE Box and Activates In Vitro Transcription of Ribosomal Protein Genes. Maldonado E, et al. Int J Mol Sci, 2023 May 30. PMID 37298423, Free PMC Article
  2. Characterisation of two novel fork-head gene homologues of Schizosaccharomyces pombe: their involvement in cell cycle and sexual differentiation. Szilagyi Z, et al. Gene, 2005 Mar 28. PMID 15777722
  3. fhl1 gene of the fission yeast regulates transcription of meiotic genes and nitrogen starvation response, downstream of the TORC1 pathway. Pataki E, et al. Curr Genet, 2017 Feb. PMID 27165118
  4. Fission Yeast TORC1 Promotes Cell Proliferation through Sfp1, a Transcription Factor Involved in Ribosome Biogenesis. Tai YT, et al. Mol Cell Biol, 2023. PMID 38051102, Free PMC Article
  5. Cdc2p controls the forkhead transcription factor Fkh2p by phosphorylation during sexual differentiation in fission yeast. Shimada M, et al. EMBO J, 2008 Jan 9. PMID 18059475, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Product of the Fission Yeast fhl1 Gene Binds to the HomolE Box and Activates In Vitro Transcription of Ribosomal Protein Genes.
    Title: The Product of the Fission Yeast fhl1 Gene Binds to the HomolE Box and Activates In Vitro Transcription of Ribosomal Protein Genes.
  2. Deletion of fhl1 (putative homologue of Saccharomyces cerevisiae FHL1) reduced the growth rate and caused an extension of cell length due to delayed G2-to-M transition.
    Title: Characterisation of two novel fork-head gene homologues of Schizosaccharomyces pombe: their involvement in cell cycle and sexual differentiation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISM
Inferred from Sequence Model
more info
 PubMed 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of ribosomal protein gene transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding forkhead transcription factor for ribosomal proteins Fhl1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    3639812..3642338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019695.3 → NP_594272.1  DNA-binding forkhead transcription factor for ribosomal proteins Fhl1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594272.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14270, Q9P7F6
    Conserved Domains (3) summary
    COG5025
    Location:1 → 564
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    cd00060
    Location:38 → 119
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:291 → 376
    Forkhead; Forkhead domain
Nucleotide Protein
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