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pli1 SUMO E3 ligase Pli1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541580, updated on 18-Sep-2024

Summary

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Official Symbol
pli1
Official Full Name
SUMO E3 ligase Pli1
Primary source
PomBase:SPAC1687.05
Locus tag
SPOM_SPAC1687.05
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See pli1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003424.3 (908696..911854)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mini-chromosome maintenance complex-binding protein mcb1 Neighboring gene ncRNA Neighboring gene ribosomal L28e protein family domain-containing protein Neighboring gene 5S ribosomal RNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SUMOylation regulates Lem2 function in centromere clustering and silencing. Strachan J, et al. J Cell Sci, 2023 Dec 1. PMID 37970674, Free PMC Article
  2. Role of the fission yeast SUMO E3 ligase Pli1p in centromere and telomere maintenance. Xhemalce B, et al. EMBO J, 2004 Oct 1. PMID 15359282, Free PMC Article
  3. Slx8 removes Pli1-dependent protein-SUMO conjugates including SUMOylated topoisomerase I to promote genome stability. Steinacher R, et al. PLoS One, 2013. PMID 23936535, Free PMC Article
  4. Pli1(PIAS1) SUMO ligase protected by the nuclear pore-associated SUMO protease Ulp1SENP1/2. Nie M, et al. J Biol Chem, 2015 Sep 11. PMID 26221037, Free PMC Article
  5. The role of Schizosaccharomyces pombe SUMO ligases in genome stability. Watts FZ, et al. Biochem Soc Trans, 2007 Dec. PMID 18031226

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SUMOylation and SUMO-dependent ubiquitylation by the Pli1-Slx8 axis contribute in different ways to maintain genome stability
    Title: Slx8 removes Pli1-dependent protein-SUMO conjugates including SUMOylated topoisomerase I to promote genome stability.
  2. study identifies the existence of an additional DNA interstrand cross-link (ICL) resolution pathway dependent on the SUMO E3 ligase Pli1
    Title: The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables SUMO ligase activity EXP
Inferred from Experiment
more info
 PubMed 
enables SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in centromere clustering at the mitotic interphase nuclear envelope IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in linear element assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in non-recombinational interstrand cross-link repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in replication fork processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stalled replication fork localization to nuclear periphery IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SUMO E3 ligase Pli1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    908696..911854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018519.3 → NP_593123.1  SUMO E3 ligase Pli1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593123.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O94451
    Conserved Domains (3) summary
    pfam02037
    Location:21 → 52
    SAP; SAP domain
    pfam02891
    Location:301 → 347
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:119 → 251
    PINIT; PINIT domain
Nucleotide Protein
Heading Accession and Version

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