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rho1 Rho family GTPase Rho1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541612, updated on 14-Nov-2024

Summary

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Official Symbol
rho1
Official Full Name
Rho family GTPase Rho1
Primary source
PomBase:SPAC1F7.04
Locus tag
SPOM_SPAC1F7.04
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See rho1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003424.3 (4224071..4225824)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene plasma membrane TRP-like calcium ion channel Pkd2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein tam6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ribonucleoside reductase large subunit Cdc22

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fission Yeast Rho1p-GEFs: From Polarity and Cell Wall Synthesis to Genome Stability. García P, et al. Int J Mol Sci, 2022 Nov 11. PMID 36430366, Free PMC Article
  2. Crystal Structure of Schizosaccharomyces pombe Rho1 Reveals Its Evolutionary Relationship with Other Rho GTPases. Huang Q, et al. Biology (Basel), 2022 Nov 7. PMID 36358328, Free PMC Article
  3. Localisation of the Schizosaccharomyces pombe rho1p GTPase and its involvement in the organisation of the actin cytoskeleton. Arellano M, et al. J Cell Sci, 1997 Oct. PMID 9372443
  4. The small GTP-binding protein Rho1 is a multifunctional protein that regulates actin localization, cell polarity, and septum formation in the fission yeast Schizosaccharomyces pombe. Nakano K, et al. Genes Cells, 1997 Nov. PMID 9491802
  5. Schizosaccharomyces pombe Rgf3p is a specific Rho1 GEF that regulates cell wall beta-glucan biosynthesis through the GTPase Rho1p. Tajadura V, et al. J Cell Sci, 2004 Dec 1. PMID 15546915

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fission Yeast Rho1p-GEFs: From Polarity and Cell Wall Synthesis to Genome Stability.
    Title: Fission Yeast Rho1p-GEFs: From Polarity and Cell Wall Synthesis to Genome Stability.
  2. both Rho1 and Pck1 are positive upstream regulatory members of the CIP in addition to Rho2 and Pck2.
    Title: Rho1 GTPase and PKC ortholog Pck1 are upstream activators of the cell integrity MAPK pathway in fission yeast.
  3. All together our results suggest that loss of Rho1 function causes an increase in the cell integrity MAPK activity, which is detrimental to the cells and turns calcineurin activity essential
    Title: Negative functional interaction between cell integrity MAPK pathway and Rho1 GTPase in fission yeast.
  4. The fission yeast cell wall stress sensor-like proteins Mtl2 and Wsc1 act by turning on the GTPase Rho1p but act independently of the cell wall integrity pathway.
    Title: The fission yeast cell wall stress sensor-like proteins Mtl2 and Wsc1 act by turning on the GTPase Rho1p but act independently of the cell wall integrity pathway.
  5. Rgf1p and Rgf2p are alternative guanine nucleotide exchange factors with an essential overlapping function in Rho1p activation during vegetative growth.
    Title: Fission yeast rgf2p is a rho1p guanine nucleotide exchange factor required for spore wall maturation and for the maintenance of cell integrity in the absence of rgf1p.
  6. Results show that Rgf1p, a Rho1p-specific GEF, acts upstream from the Pck2-Pmk1p MAPK cell integrity signaling pathway.
    Title: The Rho1p exchange factor Rgf1p signals upstream from the Pmk1 mitogen-activated protein kinase pathway in fission yeast.
  7. Rgf1p probably activates the Rho1 functions necessary for coordinating actin deposition with cell wall biosynthesis during bipolar growth, allowing the cells to remodel their wall without risk of rupture.
    Title: Rgf1p is a specific Rho1-GEF that coordinates cell polarization with cell wall biogenesis in fission yeast.
  8. Rgf3p acts as a positive activator of Rho1p, probably activating the Rho functions that coordinate cell-wall biosynthesis to maintain cell integrity during septation
    Title: Schizosaccharomyces pombe Rgf3p is a specific Rho1 GEF that regulates cell wall beta-glucan biosynthesis through the GTPase Rho1p.
  9. Results suggest that the small GTPase Rho5 has an overlapping function with the small GTPase Rho1 in controlling cell growth and division.
    Title: Small GTPase Rho5 is a functional homologue of Rho1, which controls cell shape and septation in fission yeast.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables GDP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity EXP
Inferred from Experiment
more info
 PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activator activity EXP
Inferred from Experiment
more info
 PubMed 
enables signaling adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of (1->3)-beta-D-glucan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell integrity MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic division septum assembly EXP
Inferred from Experiment
more info
 PubMed 
involved_in positive regulation of primary cell septum biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of regulation of ascospore wall (1->3)-beta-D-glucan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell wall (1->3)-beta-D-glucan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of division septum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of establishment or maintenance of cell polarity regulating cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of fungal-type cell wall (1->3)-alpha-glucan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of fungal-type cell wall biogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell cortex of growing cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic side of plasma membrane NAS
Non-traceable Author Statement
more info
  
is_active_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in division septum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in growing cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in medial cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in protein aggregate center IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Rho family GTPase Rho1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    4224071..4225824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019919.3 → NP_594490.1  Rho family GTPase Rho1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594490.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q09914
    UniProtKB/TrEMBL
    S6BDG7
    Conserved Domains (2) summary
    smart00174
    Location:9 → 182
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cd01870
    Location:6 → 180
    RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
Nucleotide Protein
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