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pol4 DNA polymerase X family [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541638, updated on 18-Sep-2024

Summary

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Official Symbol
pol4
Official Full Name
DNA polymerase X family
Primary source
PomBase:SPAC2F7.06c
Locus tag
SPOM_SPAC2F7.06C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See pol4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (541576..543557, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DYRK family cell polarity protein kinase Pom1 Neighboring gene ncRNA Neighboring gene mediator complex subunit Med1 Neighboring gene ncRNA Neighboring gene translation initiation factor Tif5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Clr6 histone deacetylase-associated PHD protein-2 Cph2 Neighboring gene SWI/SNF complex subunit Snf5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple end joining mechanisms repair a chromosomal DNA break in fission yeast. Li P, et al. DNA Repair (Amst), 2012 Feb 1. PMID 22093869
  2. Characterization of SpPol4, a unique X-family DNA polymerase in Schizosaccharomyces pombe. González-Barrera S, et al. Nucleic Acids Res, 2005. PMID 16120966, Free PMC Article
  3. ATP insertion opposite 8-oxo-deoxyguanosine by Pol4 mediates error-free tolerance in Schizosaccharomyces pombe. Sastre-Moreno G, et al. Nucleic Acids Res, 2014 Sep. PMID 25106870, Free PMC Article
  4. Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Rallis C, et al. Sci Rep, 2017 Mar 10. PMID 28281664, Free PMC Article
  5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SpPol4 incorporates ATP opposite 8oxodG almost exclusively when all nucleotides (ribos and deoxys) are provided at physiological concentrations.
    Title: ATP insertion opposite 8-oxo-deoxyguanosine by Pol4 mediates error-free tolerance in Schizosaccharomyces pombe.
  2. SpPol4 is a DNA polymerase whose enzymatic properties are hybrid of those described for mammalian Polbeta, Pollambda and Polmu.
    Title: Characterization of SpPol4, a unique X-family DNA polymerase in Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
NOT enables 3'-5' exonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5'-deoxyribose-5-phosphate lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables DNA nucleotidylexotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-directed 5'-3' RNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-directed DNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables single-strand break-containing DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in base-excision repair IC
Inferred by Curator
more info
 PubMed 
involved_in double-strand break repair via nonhomologous end joining IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via nonhomologous end joining IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in error-prone translesion synthesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in gap filling involved in double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in mating-type locus imprinting IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA polymerase X family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    541576..543557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018377.3 → NP_592977.1  DNA polymerase X family [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_592977.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q09693
    Conserved Domains (2) summary
    cd00141
    Location:180 → 503
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
    smart00483
    Location:177 → 504
    POLXc; DNA polymerase X family
Nucleotide Protein
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