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atl1 alkyltransferase-like protein Atl1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541704, updated on 18-Sep-2024

Summary

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Official Symbol
atl1
Official Full Name
alkyltransferase-like protein Atl1
Primary source
PomBase:SPAC1250.04c
Locus tag
SPOM_SPAC1250.04C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See atl1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (5096895..5097662)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ubiquitin conjugating enzyme Ubc14 Neighboring gene TFIIIC subunit Sfc7 Neighboring gene ncRNA Neighboring gene protein mug95

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel DNA damage recognition protein in Schizosaccharomyces pombe. Pearson SJ, et al. Nucleic Acids Res, 2006. PMID 16679453, Free PMC Article
  2. Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-π interactions. Wilkinson OJ, et al. Proc Natl Acad Sci U S A, 2012 Nov 13. PMID 23112169, Free PMC Article
  3. Flipping of alkylated DNA damage bridges base and nucleotide excision repair. Tubbs JL, et al. Nature, 2009 Jun 11. PMID 19516334, Free PMC Article
  4. Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines. Latypov VF, et al. Mol Cell, 2012 Jul 13. PMID 22658721, Free PMC Article
  5. A central role for TOR signalling in a yeast model for juvenile CLN3 disease. Bond ME, et al. Microb Cell, 2015 Nov 11. PMID 28357272, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-pi interactions.
    Title: Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-π interactions.
  2. Data show that alkyltransferase-like 1 (Atl1)can play a pivotal role in selecting a specific nucleotide excision repair (NER) pathway, depending on the nature of the DNA modification.
    Title: Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines.
  3. Schizosaccharomyces pombe ATL structures without and with damaged DNA containing the endogenous lesion O(6)-methylguanine or cigarette-smoke-derived O(6)-4-(3-pyridyl)-4-oxobutylguanine
    Title: Flipping of alkylated DNA damage bridges base and nucleotide excision repair.
  4. Atl1 may act by binding to O6-alkylguanine lesions and signalling them for processing by DNA repair pathways.
    Title: A novel DNA damage recognition protein in Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables O6-alkylguanine-DNA binding EXP
Inferred from Experiment
more info
 PubMed 
enables O6-alkylguanine-DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables damaged DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables methylated-DNA-[protein]-cysteine S-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in global genome nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription-coupled nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
alkyltransferase-like protein Atl1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    5096895..5097662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020287.3 → NP_594858.1  alkyltransferase-like protein Atl1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594858.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9UTN9
    Conserved Domains (2) summary
    COG0350
    Location:5 → 87
    AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
    COG3695
    Location:1 → 108
    Atl1; Alkylated DNA nucleotide flippase Atl1, participates in nucleotide excision repair, Ada-like DNA-binding domain [Transcription]
Nucleotide Protein
Heading Accession and Version

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