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adf1 cofilin [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541738, updated on 14-Nov-2024

Summary

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Official Symbol
adf1
Official Full Name
cofilin
Primary source
PomBase:SPAC20G4.06c
Locus tag
SPOM_SPAC20G4.06C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
cof1
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Genomic context

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See adf1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (4825257..4826126, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene adenylyltransferase Neighboring gene ncRNA Neighboring gene C-24(28) sterol reductase Erg4 Neighboring gene ncRNA Neighboring gene protein pdc1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin. Andrianantoandro E, et al. Mol Cell, 2006 Oct 6. PMID 17018289
  2. Fission yeast Adf1 is necessary for reassembly of actin filaments into the contractile ring during cytokinesis. Ueda EI, et al. Biochem Biophys Res Commun, 2018 Nov 25. PMID 30201262
  3. Toxoplasma gondii actin depolymerizing factor acts primarily to sequester G-actin. Mehta S, et al. J Biol Chem, 2010 Feb 26. PMID 20042603, Free PMC Article
  4. Purification of actin from fission yeast Schizosaccharomyces pombe and characterization of functional differences from muscle actin. Ti SC, et al. J Biol Chem, 2011 Feb 18. PMID 21148484, Free PMC Article
  5. Fission yeast IQGAP arranges actin filaments into the cytokinetic contractile ring. Takaine M, et al. EMBO J, 2009 Oct 21. PMID 19713940, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Adf1 is necessary for reassembly of actin filaments into the contractile ring during cytokinesis.
    Title: Fission yeast Adf1 is necessary for reassembly of actin filaments into the contractile ring during cytokinesis.
  2. These measurements support a cofilin-severing mechanism in which mechanical asymmetry promotes local stress accumulation and fragmentation at boundaries of bare and cofilin-decorated segments, analogous to failure of some nonprotein materials.
    Title: Cofilin-linked changes in actin filament flexibility promote severing.
  3. Furthermore, Cdc8, Fim1, and Adf1 all compete for association with F-actin by different mechanisms, and their cooperative association with actin filaments affects their ability to compete.
    Title: Competition between Tropomyosin, Fimbrin, and ADF/Cofilin drives their sorting to distinct actin filament networks.
  4. Cofilin rapidly dissociates Arp2/3 complex and branches by direct competition for binding sites on the actin filament and by propagation of structural changes in the actin filament that reduce affinity for Arp2/3 complex.
    Title: Cofilin dissociates Arp2/3 complex and branches from actin filaments.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin filament debranching activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin filament severing activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin monomer binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament severing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament severing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic actomyosin contractile ring assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic actomyosin contractile ring assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cortical patch IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in actin cortical patch IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cell division site HDA PubMed 
is_active_in cell tip HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in medial cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic actomyosin contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cofilin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    4825257..4826126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020169.3 → NP_594741.1  cofilin [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594741.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P78929
    Conserved Domains (1) summary
    cd11286
    Location:4 → 134
    ADF_cofilin_like; Cofilin, Destrin, and related actin depolymerizing factors
Nucleotide Protein
Heading Accession and Version

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