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alp21 tubulin-specific chaperone cofactor E [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541847, updated on 18-Sep-2024

Summary

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Official Symbol
alp21
Official Full Name
tubulin-specific chaperone cofactor E
Primary source
PomBase:SPAC22H10.10
Locus tag
SPOM_SPAC22H10.10
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
sto1
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Genomic context

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See alp21 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003424.3 (2389936..2391943)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein Cbp8 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TOR signaling pathway transcriptional corepressor Ifh1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sto1p, a fission yeast protein similar to tubulin folding cofactor E, plays an essential role in mitotic microtubule assembly. Grishchuk EL, et al. J Cell Sci, 1999 Jun. PMID 10341216
  2. The cofactor-dependent pathways for alpha- and beta-tubulins in microtubule biogenesis are functionally different in fission yeast. Radcliffe PA, et al. Genetics, 2000 Sep. PMID 10978278, Free PMC Article
  3. The dual role of fission yeast Tbc1/cofactor C orchestrates microtubule homeostasis in tubulin folding and acts as a GAP for GTPase Alp41/Arl2. Mori R, et al. Mol Biol Cell, 2013 Jun. PMID 23576550, Free PMC Article
  4. A conserved small GTP-binding protein Alp41 is essential for the cofactor-dependent biogenesis of microtubules in fission yeast. Radcliffe PA, et al. FEBS Lett, 2000 Feb 18. PMID 10683446
  5. Functional dissection and hierarchy of tubulin-folding cofactor homologues in fission yeast. Radcliffe PA, et al. Mol Biol Cell, 1999 Sep. PMID 10473641, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables alpha-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables unfolded protein binding NAS
Non-traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-chaperonin tubulin folding pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tubulin complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 
part_of tubulin folding cofactor complex NAS
Non-traceable Author Statement
more info
  

General protein information

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Preferred Names
tubulin-specific chaperone cofactor E

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2389936..2391943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019178.3 → NP_593747.1  tubulin-specific chaperone cofactor E [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593747.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q10303
    Conserved Domains (3) summary
    cd00116
    Location:146 → 329
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:117 → 142
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:115 → 179
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version

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