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bub3 mitotic spindle checkpoint WD repeat protein Bub3 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541856, updated on 18-Sep-2024

Summary

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Official Symbol
bub3
Official Full Name
mitotic spindle checkpoint WD repeat protein Bub3
Primary source
PomBase:SPAC23H3.08c
Locus tag
SPOM_SPAC23H3.08C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See bub3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003424.3 (2506085..2507369, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene AP-3 adaptor complex subunit Apl6 Neighboring gene ncRNA Neighboring gene mitochondrial 37S ribosomal protein uS14m Neighboring gene threonine aldolase Gly1 Neighboring gene ncRNA Neighboring gene tRNA-Cys

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Schizosaccharomyces pombe Bub3 is dispensable for mitotic arrest following perturbed spindle formation. Tange Y, et al. Genetics, 2008 Jun. PMID 18505884, Free PMC Article
  2. Bub1 and Bub3 promote the conversion from monopolar to bipolar chromosome attachment independently of shugoshin. Windecker H, et al. EMBO Rep, 2009 Sep. PMID 19680287, Free PMC Article
  3. The A78V mutation in the Mad3-like domain of Schizosaccharomyces pombe Bub1p perturbs nuclear accumulation and kinetochore targeting of Bub1p, Bub3p, and Mad3p and spindle assembly checkpoint function. Kadura S, et al. Mol Biol Cell, 2005 Jan. PMID 15525673, Free PMC Article
  4. Kinetochore targeting of fission yeast Mad and Bub proteins is essential for spindle checkpoint function but not for all chromosome segregation roles of Bub1p. Vanoosthuyse V, et al. Mol Cell Biol, 2004 Nov. PMID 15509783, Free PMC Article
  5. Asp1 Bifunctional Activity Modulates Spindle Function via Controlling Cellular Inositol Pyrophosphate Levels in Schizosaccharomyces pombe. Pascual-Ortiz M, et al. Mol Cell Biol, 2018 May 1. PMID 29440310, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spindle checkpoint proteins are severely depleted from unattached kinetochores in fission yeast cells lacking Bub3p.
    Title: Bub3p facilitates spindle checkpoint silencing in fission yeast.
  2. find that Bub3 is also dispensable for shugoshin localization to the centromeres, which is the second known function of Bub1.
    Title: Bub1 and Bub3 promote the conversion from monopolar to bipolar chromosome attachment independently of shugoshin.
  3. the bub3 mutation only weakly affected the stability of minichromosome Ch16 compared with other spindle assembly checkpoint mutants
    Title: Schizosaccharomyces pombe Bub3 is dispensable for mitotic arrest following perturbed spindle formation.
  4. Bub1p-A78V is defective in both nuclear accumulation and kinetochore targeting; a threshold level of nuclear Bub1p is necessary for the nuclear accumulation of Bub3p and Mad3p
    Title: The A78V mutation in the Mad3-like domain of Schizosaccharomyces pombe Bub1p perturbs nuclear accumulation and kinetochore targeting of Bub1p, Bub3p, and Mad3p and spindle assembly checkpoint function.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitotic metaphase chromosome recapture IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid biorientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of mitotic spindle assembly checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic cell cycle spindle assembly checkpoint EXP
Inferred from Experiment
more info
 PubMed 
Component Evidence Code Pubs
part_of bub1-bub3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of bub1-bub3 complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mitotic spindle checkpoint WD repeat protein Bub3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2506085..2507369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019227.3 → NP_593798.1  mitotic spindle checkpoint WD repeat protein Bub3 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593798.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O42860
    Conserved Domains (3) summary
    COG2319
    Location:8 → 294
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:15 → 54
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:8 → 291
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version

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