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alp13 Clr6 histone deacetylase complex, chromodomain subunit Alp13/Eaf3 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541858, updated on 18-Sep-2024

Summary

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Official Symbol
alp13
Official Full Name
Clr6 histone deacetylase complex, chromodomain subunit Alp13/Eaf3
Primary source
PomBase:SPAC23H4.12
Locus tag
SPOM_SPAC23H4.12
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
eaf3
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Genomic context

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See alp13 in Genome Data Viewer
Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003424.3 (1587022..1588577, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene guanyl-nucleotide exchange factor Vam6 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene centromere localized protein Cnl2 Neighboring gene ncRNA Neighboring gene bifunctional thiamine-phosphate dipyrophosphorylase/hydroxyethylthiazole kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alp13, an MRG family protein, is a component of fission yeast Clr6 histone deacetylase required for genomic integrity. Nakayama J, et al. EMBO J, 2003 Jun 2. PMID 12773392, Free PMC Article
  2. Methylations of histone H3 lysine 9 and lysine 36 are functionally linked to DNA replication checkpoint control in fission yeast. Kim HS, et al. Biochem Biophys Res Commun, 2008 Apr 4. PMID 18252195
  3. Hrp3 controls nucleosome positioning to suppress non-coding transcription in eu- and heterochromatin. Shim YS, et al. EMBO J, 2012 Nov 28. PMID 22990236, Free PMC Article
  4. Class I histone deacetylase complex: Structure and functional correlates. Wang X, et al. Proc Natl Acad Sci U S A, 2023 Jul 25. PMID 37459529, Free PMC Article
  5. Distinct roles of HDAC complexes in promoter silencing, antisense suppression and DNA damage protection. Nicolas E, et al. Nat Struct Mol Biol, 2007 May. PMID 17450151

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA repair-dependent chromatin remodeling IC
Inferred by Curator
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription initiation-coupled chromatin remodeling IC
Inferred by Curator
more info
  
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Rpd3S complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rpd3S complex IDA
Inferred from Direct Assay
more info
 PubMed 
NOT is_active_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Clr6 histone deacetylase complex, chromodomain subunit Alp13/Eaf3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    1587022..1588577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018826.3 → NP_593394.1  Clr6 histone deacetylase complex, chromodomain subunit Alp13/Eaf3 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593394.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13953
    Conserved Domains (2) summary
    pfam05712
    Location:157 → 323
    MRG; MRG
    pfam11717
    Location:6 → 57
    Tudor-knot; RNA binding activity-knot of a chromodomain
Nucleotide Protein
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