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sea3 SEA complex subunit Sea3 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541877, updated on 18-Sep-2024

Summary

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Official Symbol
sea3
Official Full Name
SEA complex subunit Sea3
Primary source
PomBase:SPAC11E3.05
Locus tag
SPOM_SPAC11E3.05
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See sea3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (5288248..5292558)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene microtubule-site clamp monopolin complex subunit Csm1/Pcs1 Neighboring gene ncRNA Neighboring gene ubiquitin-conjugating enzyme Ubc13 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA-binding transcription factor, MADS-box Map1 Neighboring gene V-type ATPase V1 subunit E Neighboring gene Smc5-6 complex non-SMC subunit Nse6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tripartite suppression of fission yeast TORC1 signaling by the GATOR1-Sea3 complex, the TSC complex, and Gcn2 kinase. Fukuda T, et al. Elife, 2021 Feb 3. PMID 33534698, Free PMC Article
  2. Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases. Chia KH, et al. Elife, 2017 Dec 4. PMID 29199950, Free PMC Article
  3. Abo1 is required for the H3K9me2 to H3K9me3 transition in heterochromatin. Dong W, et al. Sci Rep, 2020 Apr 8. PMID 32269268, Free PMC Article
  4. Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Rallis C, et al. Sci Rep, 2017 Mar 10. PMID 28281664, Free PMC Article
  5. Transcription and RNA-processing in fission yeast mitochondria. Schäfer B, et al. RNA, 2005 May. PMID 15811919, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity ISM
Inferred from Sequence Model
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
  
Process Evidence Code Pubs
involved_in cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of GATOR1 complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of GATOR2 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of Seh1-associated complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Seh1-associated complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in fungal-type vacuole membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in vacuolar membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SEA complex subunit Sea3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    5288248..5292558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020361.3 → NP_594930.1  SEA complex subunit Sea3 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594930.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13686
    Conserved Domains (5) summary
    smart00591
    Location:672 → 777
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    COG2319
    Location:105 → 488
    WD40; WD40 repeat [General function prediction only]
    pfam17120
    Location:1259 → 1318
    Zn_ribbon_17; Zinc-ribbon, C4HC2 type
    sd00039
    Location:278 → 319
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:288 → 541
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version

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