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cdc15 F-BAR domain protein Cdc15 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541975, updated on 18-Sep-2024

Summary

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Official Symbol
cdc15
Official Full Name
F-BAR domain protein Cdc15
Primary source
PomBase:SPAC20G8.05c
Locus tag
SPOM_SPAC20G8.05C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See cdc15 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003424.3 (1399200..1402936, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene plasma membrane myo-inositol transmembrane transporter Neighboring gene electron transfer flavoprotein-ubiquinone oxidoreductase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CCR4-Not complex subunit Not1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Organization of a sterol-rich membrane domain by cdc15p during cytokinesis in fission yeast. Takeda T, et al. Nat Cell Biol, 2004 Nov. PMID 15517003
  2. Contractile ring stability in S. pombe depends on F-BAR protein Cdc15p and Bgs1p transport from the Golgi complex. Arasada R, et al. Cell Rep, 2014 Sep 11. PMID 25159149, Free PMC Article
  3. Fission yeast paxillin contains two Cdc15 binding motifs for robust recruitment to the cytokinetic ring. Snider CE, et al. Mol Biol Cell, 2022 Apr 1. PMID 35108037, Free PMC Article
  4. The Tubulation Activity of a Fission Yeast F-BAR Protein Is Dispensable for Its Function in Cytokinesis. McDonald NA, et al. Cell Rep, 2016 Jan 26. PMID 26776521, Free PMC Article
  5. The S. pombe cdc15 gene is a key element in the reorganization of F-actin at mitosis. Fankhauser C, et al. Cell, 1995 Aug 11. PMID 7634333

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast.
    Title: Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast.
  2. Cdk1 phosphorylation of formin Cdc12 antagonizes its interaction with Cdc15 and thereby opposes Cdc12's contractile ring localization. These results are consistent with a general role for Cdk1 in inhibiting cytokinesis until chromosome segregation is complete.
    Title: Cdk1-dependent phosphoinhibition of a formin-F-BAR interaction opposes cytokinetic contractile ring formation.
  3. Septation initiation network and Clp1p/Flp1p contribute to maintenance of the actomyosin ring in late mitosis through Cdc15p, possibly by regulating its phosphorylation status.(Cdc15) (actomyosin)
    Title: Cell cycle-dependent roles for the FCH-domain protein Cdc15p in formation of the actomyosin ring in Schizosaccharomyces pombe.
  4. Data indicate that the SH3 domains of Cdc15 and contractile ring protein Imp2 cooperate in the essential process of recruiting other proteins to stabilize the contractile ring.
    Title: The Cdc15 and Imp2 SH3 domains cooperatively scaffold a network of proteins that redundantly ensure efficient cell division in fission yeast.
  5. Cdc15p associates with trans-Golgi membranes through its middle domain and controls Bgs1 delivery from the Golgi apparatus to the plasma membrane.
    Title: Contractile ring stability in S. pombe depends on F-BAR protein Cdc15p and Bgs1p transport from the Golgi complex.
  6. Cdc15 contributes to contractile ring formation and cytokinesis via formin Cdc12 recruitment, defining a novel cytokinetic function for an F-BAR domain.
    Title: The F-BAR Cdc15 promotes contractile ring formation through the direct recruitment of the formin Cdc12.
  7. The F-BAR proteins Cdc15p and Bzz1p accumulate in two distinct zones on invaginating membrane tubules, interacting with nucleation-promoting factors for Arp2/3 complex. They peak prior to movement of the actin patch.
    Title: Distinct roles for F-BAR proteins Cdc15p and Bzz1p in actin polymerization at sites of endocytosis in fission yeast.
  8. Cdc15 phosphoregulation impels both assembly and disassembly of the contractile apparatus.
    Title: Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.
  9. The SH3 domains of Cdc15 and Imp2 play a cooperative and essential role in cytokinesis.
    Title: The SH3 domains of two PCH family members cooperate in assembly of the Schizosaccharomyces pombe contractile ring.
  10. cdc15p functions to organize lipid rafts at the cleavage site for cytokinesis
    Title: Organization of a sterol-rich membrane domain by cdc15p during cytokinesis in fission yeast.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables cytoskeletal protein-membrane anchor activity EXP
Inferred from Experiment
more info
 PubMed 
enables cytoskeletal protein-membrane anchor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cytoskeletal protein-membrane anchor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cytoskeletal protein-membrane anchor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in clathrin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of bipolar cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in membrane bending IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic actomyosin contractile ring assembly EXP
Inferred from Experiment
more info
 PubMed 
involved_in mitotic actomyosin contractile ring assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic actomyosin contractile ring assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cortical patch IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell division site HDA PubMed 
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell tip HDA PubMed 
is_active_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mating projection tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in medial cortical node IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in medial membrane band IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic actomyosin contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic actomyosin contractile ring, proximal layer IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic actomyosin contractile ring, proximal layer IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
F-BAR domain protein Cdc15

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    1399200..1402936 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018753.3 → NP_593322.1  F-BAR domain protein Cdc15 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593322.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14365, Q09822, Q9UU50
    Conserved Domains (2) summary
    cd07651
    Location:28 → 263
    F-BAR_PombeCdc15_like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Schizosaccharomyces pombe Cdc15, and similar proteins
    smart00326
    Location:869 → 925
    SH3; Src homology 3 domains
Nucleotide Protein
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