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pnk1 DNA kinase/phosphatase Pnk1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542032, updated on 14-Nov-2024

Summary

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Official Symbol
pnk1
Official Full Name
DNA kinase/phosphatase Pnk1
Primary source
PomBase:SPAC23C11.04c
Locus tag
SPOM_SPAC23C11.04C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See pnk1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003424.3 (2136034..2139467, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene family protein ICE2 Neighboring gene 40S ribosomal protein uS12 Neighboring gene U3 snoRNP-associated protein Mpp1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene hydrolase Neighboring gene ncRNA Neighboring gene inorganic pyrophosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pnk1, a DNA kinase/phosphatase required for normal response to DNA damage by gamma-radiation or camptothecin in Schizosaccharomyces pombe. Meijer M, et al. J Biol Chem, 2002 Feb 8. PMID 11729194
  2. Purification and partial characterization of a DNA 3'-phosphatase from Schizosaccharomyces pombe. Jilani A, et al. Biochemistry, 2002 Jun 18. PMID 12056900
  3. Polynucleotide kinase/phosphatase, Pnk1, is involved in base excision repair in Schizosaccharomyces pombe. Kashkina E, et al. DNA Repair (Amst), 2012 Aug 1. PMID 22748672
  4. Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks. Ganguly A, et al. PLoS Genet, 2018 Aug. PMID 30148840, Free PMC Article
  5. Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in the polynucleotide kinase/phosphatase mutant of fission yeast. Sanchez A, et al. PLoS Genet, 2017 Sep. PMID 28922417, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables polynucleotide 3'-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polynucleotide 3'-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables polynucleotide 3'-phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in base-excision repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in single strand break repair IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleolus HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA kinase/phosphatase Pnk1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2136034..2139467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019066.3 → NP_593635.2  DNA kinase/phosphatase Pnk1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593635.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13911
    Conserved Domains (4) summary
    cd01427
    Location:71 → 212
    HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
    pfam08645
    Location:70 → 220
    PNK3P; Polynucleotide kinase 3 phosphatase
    pfam13671
    Location:258 → 379
    AAA_33; AAA domain
    cl17190
    Location:258 → 366
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
Nucleotide Protein
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