U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

trx1 cytosolic thioredoxin Trx1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542084, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
trx1
Official Full Name
cytosolic thioredoxin Trx1
Primary source
PomBase:SPAC7D4.07c
Locus tag
SPOM_SPAC7D4.07C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See trx1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (2625313..2625855)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene steroid dehydrogenase Neighboring gene uncharacterized protein Neighboring gene oligosaccharyltransferase subunit Ost4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene dolichol-P-Man-dependent alpha(1-3) mannosyltransferase Alg3

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The role and regulation of Trxl, a cytosolic thioredoxin in Schizosaccharomyces pombe. Song JY, et al. J Microbiol, 2008 Aug. PMID 18758731
  2. Characterization and regulation of Schizosaccharomyces pombe gene encoding thioredoxin. Cho Y, et al. Biochim Biophys Acta, 2001 Mar 19. PMID 11267679
  3. A peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms. Cao M, et al. Mol Cell, 2023 Sep 7. PMID 37572670
  4. Characterization and regulation of a second gene encoding thioredoxin from the fission yeast. Lee YJ, et al. Biochim Biophys Acta, 2002 May 3. PMID 12020831
  5. Gpx1 is a stationary phase-specific thioredoxin peroxidase in fission yeast. Lee SY, et al. Biochem Biophys Res Commun, 2008 Feb 29. PMID 18162174

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We propose that in a mutant strain compromised in reducing equivalents, the absence of an abundant and competitive substrate such as the peroxiredoxin Tpx1 has been selected as a lethality suppressor to favor RNR function at the expense of the non-essential peroxide scavenging function, to allow DNA synthesis and cell growth.
    Title: Lack of a peroxiredoxin suppresses the lethality of cells devoid of electron donors by channelling electrons to oxidized ribonucleotide reductase.
  2. our data establish that redox-coupling between Trx1 and the thioredoxin peroxidase activity of Tpx1 is central for initiation of appropriate responses to different levels of hydrogen peroxide in S. pombe
    Title: Inactivation of a peroxiredoxin by hydrogen peroxide is critical for thioredoxin-mediated repair of oxidized proteins and cell survival.
  3. Trxl plays a major role in protecting S. pombe against various stressful conditions and enables proper sulfur metabolism.
    Title: The role and regulation of Trxl, a cytosolic thioredoxin in Schizosaccharomyces pombe.
  4. These results indicate that glutathione reductase is essential in the aerobic growth of S. pombe due to its role in maintaining oxidation-labile Fe-S enzymes and iron homeostasis through mitochondrial thioredoxin Trx2.
    Title: Glutathione reductase and a mitochondrial thioredoxin play overlapping roles in maintaining iron-sulfur enzymes in fission yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables antioxidant activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-disulfide reductase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein-disulfide reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-disulfide reductase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein-disulfide reductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-methionine salvage from methionine sulphoxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular detoxification of hydrogen peroxide IC
Inferred by Curator
more info
  
involved_in cellular response to reactive oxygen species IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in hydrogen peroxide catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
cytosolic thioredoxin Trx1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2625313..2625855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019281.3 → NP_593852.1  cytosolic thioredoxin Trx1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593852.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14463, P58265, Q9UTS9
    Conserved Domains (1) summary
    cd02947
    Location:9 → 100
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.