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ubp8 SAGA complex ubiquitin Ubp8 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542135, updated on 14-Nov-2024

Summary

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Official Symbol
ubp8
Official Full Name
SAGA complex ubiquitin Ubp8
Primary source
PomBase:SPAC13A11.04c
Locus tag
SPOM_SPAC13A11.04C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See ubp8 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003424.3 (579353..581480, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein Mcp7 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene peptidase family M17 cytoplasmic leucyl aminopeptidase yspII (LAP yspII)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Whole-Genome Sequencing of Suppressor DNA Mixtures Identifies Pathways That Compensate for Chromosome Segregation Defects in Schizosaccharomyces pombe. Xu X, et al. G3 (Bethesda), 2018 Mar 2. PMID 29352077, Free PMC Article
  2. Histone H2B ubiquitination promotes the function of the anaphase-promoting complex/cyclosome in Schizosaccharomyces pombe. Elmore ZC, et al. G3 (Bethesda), 2014 Jun 19. PMID 24948786, Free PMC Article
  3. TOR complex 2 contributes to regulation of gene expression via inhibiting Gcn5 recruitment to subtelomeric and DNA replication stress genes. Cohen A, et al. PLoS Genet, 2022 Feb. PMID 35157728, Free PMC Article
  4. Anti-silencing factor Epe1 associates with SAGA to regulate transcription within heterochromatin. Bao K, et al. Genes Dev, 2019 Jan 1. PMID 30573453, Free PMC Article
  5. The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8. Helmlinger D, et al. Genes Dev, 2008 Nov 15. PMID 19056896, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ubp8 antagonizes the anaphase-promoting complex/cyclosome function indirectly by modulating H2B ubiquitination status
    Title: Histone H2B ubiquitination promotes the function of the anaphase-promoting complex/cyclosome in Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal-dependent deubiquitinase activity HDA PubMed 
enables transcription coactivator activity IC
Inferred by Curator
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II EXP
Inferred from Experiment
more info
 PubMed 
involved_in transcription initiation-coupled chromatin remodeling IC
Inferred by Curator
more info
  
Component Evidence Code Pubs
part_of DUBm complex NAS
Non-traceable Author Statement
more info
  
part_of SAGA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SAGA complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT is_active_in nucleolus HDA PubMed 
is_active_in nucleoplasm HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SAGA complex ubiquitin Ubp8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    579353..581480 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018391.3 → NP_592992.1  SAGA complex ubiquitin Ubp8 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_592992.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q09738
    Conserved Domains (3) summary
    smart00290
    Location:37 → 85
    ZnF_UBP; Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger
    cd02660
    Location:145 → 433
    Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:144 → 432
    UCH; Ubiquitin carboxyl-terminal hydrolase
Nucleotide Protein
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