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nup124 nucleoporin Nup124 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542254, updated on 18-Sep-2024

Summary

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Official Symbol
nup124
Official Full Name
nucleoporin Nup124
Primary source
PomBase:SPAC30D11.04c
Locus tag
SPOM_SPAC30D11.04C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See nup124 in Genome Data Viewer
Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003424.3 (1112175..1115868)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene transporter Hfl1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene AP-3 adaptor complex subunit Aps3 Neighboring gene ncRNA Neighboring gene putative ATP-dependent RNA helicase Ddx27/Drs1 Neighboring gene uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nup124p is a nuclear pore factor of Schizosaccharomyces pombe that is important for nuclear import and activity of retrotransposon Tf1. Balasundaram D, et al. Mol Cell Biol, 1999 Aug. PMID 10409764, Free PMC Article
  2. The functionally conserved nucleoporins Nup124p from fission yeast and the human Nup153 mediate nuclear import and activity of the Tf1 retrotransposon and HIV-1 Vpr. Varadarajan P, et al. Mol Biol Cell, 2005 Apr. PMID 15659641, Free PMC Article
  3. Multiple conserved domains of the nucleoporin Nup124p and its orthologs Nup1p and Nup153 are critical for nuclear import and activity of the fission yeast Tf1 retrotransposon. Sistla S, et al. Mol Biol Cell, 2007 Sep. PMID 17615301, Free PMC Article
  4. Selective Nuclear Pore Complex Removal Drives Nuclear Envelope Division in Fission Yeast. Expósito-Serrano M, et al. Curr Biol, 2020 Aug 17. PMID 32502403
  5. Characterization of nuclear pore complex components in fission yeast Schizosaccharomyces pombe. Asakawa H, et al. Nucleus, 2014 Mar-Apr. PMID 24637836, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Although full-length Nup1p or Nup153 does not complement Nup124p, the functionality of their conserved domains with reference to Tf1 activity suggests that these three proteins evolved from a common ancestor.
    Title: Multiple conserved domains of the nucleoporin Nup124p and its orthologs Nup1p and Nup153 are critical for nuclear import and activity of the fission yeast Tf1 retrotransposon.
  2. required for the nuclear import of both retrotransposon Tf1-Gag as well as the retroviral HIV-1 Vpr; Nup124 shares a unique N-terminal domain with Nup153 that is absolutely essential for Tf1 transposition
    Title: The functionally conserved nucleoporins Nup124p from fission yeast and the human Nup153 mediate nuclear import and activity of the Tf1 retrotransposon and HIV-1 Vpr.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal subunit export from nucleus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitotic nuclear bridge midzone membrane domain IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear envelope HDA PubMed 
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nucleoporin Nup124

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    1112175..1115868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018609.3 → NP_593213.1  nucleoporin Nup124 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593213.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q09904
    Conserved Domains (1) summary
    pfam10599
    Location:1072 → 1158
    Nup_retrotrp_bd; Retro-transposon transporting motif
Nucleotide Protein
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