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hst4 histone deacetylase, Sirtuin family, NAD-dependent Hst4 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542366, updated on 14-Nov-2024

Summary

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Official Symbol
hst4
Official Full Name
histone deacetylase, Sirtuin family, NAD-dependent Hst4
Primary source
PomBase:SPAC1783.04c
Locus tag
SPOM_SPAC1783.04C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See hst4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003424.3 (2192037..2193615, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene methionine synthase reductase Neighboring gene ncRNA Neighboring gene acyltransferase Neighboring gene CENP-P family protein Fta2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CENP-A chaperone, CHD family Hrp1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Schizosaccharomyces pombe hst4(+) gene is a SIR2 homologue with silencing and centromeric functions. Freeman-Cook LL, et al. Mol Biol Cell, 1999 Oct. PMID 10512858, Free PMC Article
  2. The role of MutY homolog (Myh1) in controlling the histone deacetylase Hst4 in the fission yeast Schizosaccharomyces pombe. Chang DY, et al. J Mol Biol, 2011 Jan 21. PMID 21110984, Free PMC Article
  3. Fission Yeast Sirtuin Hst4 Functions in Preserving Genomic Integrity by Regulating Replisome Component Mcl1. Konada L, et al. Sci Rep, 2018 May 31. PMID 29855479, Free PMC Article
  4. Anaphase-promoting complex/cyclosome-mediated proteolysis of Ams2 in the G1 phase ensures the coupling of histone gene expression to DNA replication in fission yeast. Trickey M, et al. J Biol Chem, 2013 Jan 11. PMID 23195958, Free PMC Article
  5. Specific functions for the fission yeast Sirtuins Hst2 and Hst4 in gene regulation and retrotransposon silencing. Durand-Dubief M, et al. EMBO J, 2007 May 16. PMID 17446861, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks.
    Title: DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks.
  2. The deletion of hst4 causes S phase delay and DNA synthesis defects, which are partially suppressed by overexpression of mcl1. The sensitivity of hst4Delta mutant cells to agents that cause replication stress (MMS, HU), with an exception to camptothecin, are completely rescued by expression of mcl1.
    Title: Fission Yeast Sirtuin Hst4 Functions in Preserving Genomic Integrity by Regulating Replisome Component Mcl1.
  3. These results suggest that SpMyh1 repair regulates the functions of SpHst4 and the 9-1-1 complex in maintaining genomic stability.
    Title: The role of MutY homolog (Myh1) in controlling the histone deacetylase Hst4 in the fission yeast Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K14 deacetylase activity, NAD-dependent EXP
Inferred from Experiment
more info
 PubMed 
enables histone H3K18 deacetylase activity, NAD-dependent IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K4 deacetylase activity, NAD-dependent IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K56 deacetylase activity, NAD-dependent IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H3K9 deacetylase activity, NAD-dependent IEA
Inferred from Electronic Annotation
more info
  
enables histone H4K16 deacetylase activity, NAD-dependent IEA
Inferred from Electronic Annotation
more info
  
enables histone deacetylase activity, NAD-dependent IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA repair-dependent chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pericentric heterochromatin formation EXP
Inferred from Experiment
more info
 PubMed 
involved_in pericentric heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pericentric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rDNA heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in replication-born double-strand break repair via sister chromatid exchange IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in subtelomeric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromosome, subtelomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mating-type region heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mating-type region heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in pericentric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in rDNA heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histone deacetylase, Sirtuin family, NAD-dependent Hst4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2192037..2193615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019091.3 → NP_593659.1  histone deacetylase, Sirtuin family, NAD-dependent Hst4 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593659.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9UR39
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials