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cpp1 protein farnesyltransferase beta subunit Cpp1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542380, updated on 18-Sep-2024

Summary

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Official Symbol
cpp1
Official Full Name
protein farnesyltransferase beta subunit Cpp1
Primary source
PomBase:SPAC17G6.04c
Locus tag
SPOM_SPAC17G6.04C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See cpp1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (3592994..3596406, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene ncRNA Neighboring gene phosphoprotein phosphatase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene vacuolar protein-sorting protein Neighboring gene ncRNA Neighboring gene 40S ribosomal protein eS24

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation of a fission yeast mutant cell affected in MAP kinase signaling and sterol biosynthesis. Imagawa K, et al. Kobe J Med Sci, 2009 Jun 5. PMID 20847589
  2. Distinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase. Murai T, et al. Genetics, 2009 Oct. PMID 19620394, Free PMC Article
  3. Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe. Yang W, et al. J Biol Chem, 2000 Jan 7. PMID 10617635
  4. Rho2 is a target of the farnesyltransferase Cpp1 and acts upstream of Pmk1 mitogen-activated protein kinase signaling in fission yeast. Ma Y, et al. Mol Biol Cell, 2006 Dec. PMID 17005909, Free PMC Article
  5. A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex. Nakase Y, et al. Genetics, 2006 Jun. PMID 16624901, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results demonstrate that Cpp1 is a key component of the Pck2-Pmk1 signaling through the spatial control of the small GTPase Rho2.
    Title: Rho2 is a target of the farnesyltransferase Cpp1 and acts upstream of Pmk1 mitogen-activated protein kinase signaling in fission yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by PomBase

Function Evidence Code Pubs
contributes_to protein farnesyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to protein farnesyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein farnesyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein localization to plasma membrane IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 
part_of protein farnesyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein farnesyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
protein farnesyltransferase beta subunit Cpp1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    3592994..3596406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019674.3 → NP_594251.1  protein farnesyltransferase beta subunit Cpp1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594251.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13782
    Conserved Domains (2) summary
    COG5029
    Location:4 → 376
    CAL1; Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism]
    cd02893
    Location:32 → 327
    FTase; Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the ...
Nucleotide Protein
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