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rtf2 DNA replication termination factor Rtf2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542468, updated on 18-Sep-2024

Summary

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Official Symbol
rtf2
Official Full Name
DNA replication termination factor Rtf2
Primary source
PomBase:SPAC1D4.09c
Locus tag
SPOM_SPAC1D4.09C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See rtf2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003424.3 (652225..653272, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene cyclin-dependent kinase-activating kinase Csk1 Neighboring gene ncRNA Neighboring gene phosphatidylinositol synthase (CDP-diacylglycerol--inositol 3-phosphatidyltransferase) Pis1 Neighboring gene ncRNA Neighboring gene 3' tRNA-processing endonuclease tRNAse Z L2 Trz1 Neighboring gene ncRNA Neighboring gene dual-specificity

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Schizosaccharomyces pombe Rtf2 is important for replication fork barrier activity of RTS1 via splicing of Rtf1. Budden AM, et al. Elife, 2023 Aug 24. PMID 37615341, Free PMC Article
  2. Schizosaccharomyces pombe Rtf2 mediates site-specific replication termination by inhibiting replication restart. Inagawa T, et al. Proc Natl Acad Sci U S A, 2009 May 12. PMID 19416828, Free PMC Article
  3. Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts. Anver S, et al. EMBO Rep, 2014 Aug. PMID 24957674, Free PMC Article
  4. Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Rallis C, et al. Sci Rep, 2017 Mar 10. PMID 28281664, Free PMC Article
  5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rtf2 stabilizes the replication fork stalled at RTS1 until completion of DNA synthesis by a converging replication fork initiated at a flanking origin
    Title: Schizosaccharomyces pombe Rtf2 mediates site-specific replication termination by inhibiting replication restart.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome EXP
Inferred from Experiment
more info
 PubMed 
NOT involved_in replication fork arrest EXP
Inferred from Experiment
more info
 PubMed 
NOT involved_in replication fork processing EXP
Inferred from Experiment
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
NOT is_active_in replication fork EXP
Inferred from Experiment
more info
 PubMed 
part_of spliceosomal complex EXP
Inferred from Experiment
more info
 PubMed 

General protein information

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Preferred Names
DNA replication termination factor Rtf2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    652225..653272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018421.3 → NP_593022.1  DNA replication termination factor Rtf2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593022.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q10154
    UniProtKB/TrEMBL
    C1M2W1
    Conserved Domains (1) summary
    pfam04641
    Location:1 → 239
    Rtf2; Rtf2 RING-finger
Nucleotide Protein
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