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gsk3 serine/threonine protein kinase Gsk3 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542652, updated on 18-Sep-2024

Summary

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Official Symbol
gsk3
Official Full Name
serine/threonine protein kinase Gsk3
Primary source
PomBase:SPAC1687.15
Locus tag
SPOM_SPAC1687.15
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
skp1
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Genomic context

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See gsk3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (929831..932197)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene calcium-binding protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C-5 sterol desaturase Erg31 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3. Wang T, et al. Life Sci Alliance, 2022 May. PMID 35121625, Free PMC Article
  2. Schizosaccharomyces pombe skp1+ encodes a protein kinase related to mammalian glycogen synthase kinase 3 and complements a cdc14 cytokinesis mutant. Plyte SE, et al. Mol Cell Biol, 1996 Jan. PMID 8524294, Free PMC Article
  3. Genetic Interactions among AMPK Catalytic Subunit Ssp2 and Glycogen Synthase Kinases Gsk3 and Gsk31 in Schizosaccharomyces Pombe. Qingyun, et al. Kobe J Med Sci, 2016 Aug 3. PMID 27604537, Free PMC Article
  4. AMPKα Subunit Ssp2 and Glycogen Synthase Kinases Gsk3/Gsk31 are involved in regulation of sterol regulatory element-binding protein (SREBP) activity in fission yeast. Miao H, et al. PLoS One, 2020. PMID 32053662, Free PMC Article
  5. The role of Ppe1/PP6 phosphatase for equal chromosome segregation in fission yeast kinetochore. Goshima G, et al. EMBO J, 2003 Jun 2. PMID 12773390, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3.
    Title: Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3.
  2. Data indicate that AMP-activated protein kinase beta subunit Amk2 (Amk2) and glycogen synthase kinase 3 (Gsk3) act in parallel to inhibit TORC1 (Tor2) function.
    Title: Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
  3. Overexpression of the gsk3+ gene or the gsk31+ gene, another GSK3 member, rescues defective growth of Deltassp2 cells at restrictive temperatures and under glucose depletion as well as sexual differentiation under nitrogen depletion.
    Title: Genetic Interactions among AMPK Catalytic Subunit Ssp2 and Glycogen Synthase Kinases Gsk3 and Gsk31 in Schizosaccharomyces Pombe.
  4. Skp1 plays role in the checkpoint-signalling cascade.
    Title: Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine/tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in SREBP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of kinetochore assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine protein kinase Gsk3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    929831..932197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018530.3 → NP_593134.1  serine/threonine protein kinase Gsk3 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593134.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O94456, Q10452
    Conserved Domains (2) summary
    smart00220
    Location:32 → 316
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14137
    Location:28 → 319
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
Nucleotide Protein
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