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sgo2 shugoshin Sgo2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542788, updated on 14-Nov-2024

Summary

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Official Symbol
sgo2
Official Full Name
shugoshin Sgo2
Primary source
PomBase:SPAC15A10.15
Locus tag
SPOM_SPAC15A10.15
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See sgo2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003424.3 (3714142..3716585)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein kinase domain and HEAT repeat protein Ppk3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene actin-interacting protein 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bub1 kinase- and H2A phosphorylation-independent regulation of Shugoshin proteins under glucose-restricted conditions. Kobayashi Y, et al. Sci Rep, 2019 Feb 26. PMID 30809004, Free PMC Article
  2. Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing. Tashiro S, et al. Nat Commun, 2016 Jan 25. PMID 26804021, Free PMC Article
  3. Two fission yeast homologs of Drosophila Mei-S332 are required for chromosome segregation during meiosis I and II. Rabitsch KP, et al. Curr Biol, 2004 Feb 17. PMID 14972679
  4. Aurora controls sister kinetochore mono-orientation and homolog bi-orientation in meiosis-I. Hauf S, et al. EMBO J, 2007 Oct 31. PMID 17932486, Free PMC Article
  5. Shugoshin 2 regulates localization of the chromosomal passenger proteins in fission yeast mitosis. Vanoosthuyse V, et al. Mol Biol Cell, 2007 May. PMID 17301288, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bub1 kinase- and H2A phosphorylation-independent regulation of Shugoshin proteins under glucose-restricted conditions.
    Title: Bub1 kinase- and H2A phosphorylation-independent regulation of Shugoshin proteins under glucose-restricted conditions.
  2. Sgo2 interacts with Bir1/Survivin and promotes Aurora kinase complex localization to the pericentromeric region, to correct erroneous attachment of kinetochores and thereby enable tension-generating attachment. (sgo2) (ark1)
    Title: Shugoshin enables tension-generating attachment of kinetochores by loading Aurora to centromeres.
  3. findings show that Bub1 phosphorylates the conserved serine 121 of histone H2A; Bub1 kinase creates a mark for shugoshin localization and the correct partitioning of chromosomes
    Title: Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin.
  4. Sgo2, which assists in loading Aurora to centromeres, and its regulator Bub1 are required for the mono-orientation of sister chromatids in meiosis-I, while Ark1 is required for the faithful bi-orientation
    Title: Aurora controls sister kinetochore mono-orientation and homolog bi-orientation in meiosis-I.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables chromatin-protein adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in homologous chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid biorientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromosome, subtelomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm HDA PubMed 
is_active_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in meiotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in pericentric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
shugoshin Sgo2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    3714142..3716585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019724.3 → NP_594301.1  shugoshin Sgo2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594301.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13734, Q9UU02
    Conserved Domains (2) summary
    pfam07557
    Location:572 → 593
    Shugoshin_C; Shugoshin C terminus
    pfam07558
    Location:13 → 57
    Shugoshin_N; Shugoshin N-terminal coiled-coil region
Nucleotide Protein
Heading Accession and Version

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