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ain1 alpha-actinin [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542805, updated on 18-Sep-2024

Summary

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Official Symbol
ain1
Official Full Name
alpha-actinin
Primary source
PomBase:SPAC15A10.08
Locus tag
SPOM_SPAC15A10.08
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See ain1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (3692790..3695013)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene CPA1 sodium ion/proton antiporter Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SUR7 family protein Neighboring gene muskelin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterisation of Schizosaccharomyces pombe α-actinin. Addario B, et al. PeerJ, 2016. PMID 27069798, Free PMC Article
  2. Molecular dissection of the actin-binding ability of the fission yeast α-actinin, Ain1, in vitro and in vivo. Morita R, et al. J Biochem, 2017 Aug 1. PMID 28338873
  3. Cooperation between tropomyosin and α-actinin inhibits fimbrin association with actin filament networks in fission yeast. Christensen JR, et al. Elife, 2019 Jun 10. PMID 31180322, Free PMC Article
  4. The F-actin bundler α-actinin Ain1 is tailored for ring assembly and constriction during cytokinesis in fission yeast. Li Y, et al. Mol Biol Cell, 2016 Jun 1. PMID 27075176, Free PMC Article
  5. ER-PM Contacts Define Actomyosin Kinetics for Proper Contractile Ring Assembly. Zhang D, et al. Curr Biol, 2016 Mar 7. PMID 26877082, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data sugest that fimbrin (Fim1) competes with alpha-actinin (Ain1) for association with F-actin, and prevents tropomyosin Cdc8's association with actin patches.
    Title: Cooperation between tropomyosin and α-actinin inhibits fimbrin association with actin filament networks in fission yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables actin filament binding EXP
Inferred from Experiment
more info
 PubMed 
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin lateral binding EXP
Inferred from Experiment
more info
 PubMed 
enables actin lateral binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin crosslink formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament bundle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin filament bundle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actomyosin contractile ring assembly actin filament bundle convergence IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin filament bundle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in actin filament bundle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in actomyosin contractile ring IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cell projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic actomyosin contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
alpha-actinin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    3692790..3695013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019718.3 → NP_594295.1  alpha-actinin [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594295.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13728
    Conserved Domains (3) summary
    COG5069
    Location:1 → 616
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00014
    Location:125 → 229
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam08726
    Location:554 → 615
    EFhand_Ca_insen; Ca2+ insensitive EF hand
Nucleotide Protein
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