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srw1 substrate-specific mitotic G1 APC coactivator Srw1/Ste9 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542824, updated on 18-Sep-2024

Summary

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Official Symbol
srw1
Official Full Name
substrate-specific mitotic G1 APC coactivator Srw1/Ste9
Primary source
PomBase:SPAC144.13c
Locus tag
SPOM_SPAC144.13C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
ste9
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Genomic context

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See srw1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (4677611..4680193, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 40S ribosomal protein uS17 Neighboring gene ribose 5-phosphate isomerase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene kinesin-like protein Klp8 Neighboring gene COG complex subunit Cog1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The fission yeast APC activator Ste9 is regulated by mRNA decay. Alvarez B, et al. Cell Cycle, 2006 Apr. PMID 16627999
  2. Fission yeast Fizzy-related protein srw1p is a G(1)-specific promoter of mitotic cyclin B degradation. Yamaguchi S, et al. EMBO J, 2000 Aug 1. PMID 10921878, Free PMC Article
  3. A Cds1-mediated checkpoint protects the MBF activator Rep2 from ubiquitination by anaphase-promoting complex/cyclosome-Ste9 at S-phase arrest in fission yeast. Chu Z, et al. Mol Cell Biol, 2009 Sep. PMID 19596787, Free PMC Article
  4. APC(ste9/srw1) promotes degradation of mitotic cyclins in G(1) and is inhibited by cdc2 phosphorylation. Blanco MA, et al. EMBO J, 2000 Aug 1. PMID 10921876, Free PMC Article
  5. Anaphase-promoting complex/cyclosome-mediated proteolysis of Ams2 in the G1 phase ensures the coupling of histone gene expression to DNA replication in fission yeast. Trickey M, et al. J Biol Chem, 2013 Jan 11. PMID 23195958, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cds1-dependent stabilization of Rep2 is achieved through the inhibition/phosphorylation of APC/C-Ste9 at the onset of S-phase arrest.
    Title: A Cds1-mediated checkpoint protects the MBF activator Rep2 from ubiquitination by anaphase-promoting complex/cyclosome-Ste9 at S-phase arrest in fission yeast.
  2. Ste9 is regulated by mRNA decay
    Title: The fission yeast APC activator Ste9 is regulated by mRNA decay.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables anaphase-promoting complex binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin ligase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin ligase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin ligase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaphase-promoting complex-dependent catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anaphase-promoting complex-dependent catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic G1 cell size control checkpoint signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic G1 cell size control checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of anaphase-promoting complex-dependent catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
substrate-specific mitotic G1 APC coactivator Srw1/Ste9

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    4677611..4680193 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020103.3 → NP_594674.1  substrate-specific mitotic G1 APC coactivator Srw1/Ste9 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594674.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A7VJ97, O13286
    Conserved Domains (3) summary
    COG2319
    Location:272 → 536
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:291 → 532
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:295 → 331
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version

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