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rgf2 RhoGEF for Rho1 Rgf2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542953, updated on 18-Sep-2024

Summary

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Official Symbol
rgf2
Official Full Name
RhoGEF for Rho1 Rgf2
Primary source
PomBase:SPAC1006.06
Locus tag
SPOM_SPAC1006.06
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See rgf2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (5080718..5085055)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene protein mcp3 Neighboring gene ncRNA Neighboring gene Golgi alpha-1,6-mannosyltransferase Och1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene translation initiation factor eIF4A Tif1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fission yeast rgf2p is a rho1p guanine nucleotide exchange factor required for spore wall maturation and for the maintenance of cell integrity in the absence of rgf1p. García P, et al. Genetics, 2009 Apr. PMID 19189958, Free PMC Article
  2. Rho1-GEFs Rgf1 and Rgf2 are involved in formation of cell wall and septum, while Rgf3 is involved in cytokinesis in fission yeast. Mutoh T, et al. Genes Cells, 2005 Dec. PMID 16324155
  3. The checkpoint-dependent nuclear accumulation of Rho1p exchange factor Rgf1p is important for tolerance to chronic replication stress. Muñoz S, et al. Mol Biol Cell, 2014 Apr. PMID 24478458, Free PMC Article
  4. The fission yeast cell wall stress sensor-like proteins Mtl2 and Wsc1 act by turning on the GTPase Rho1p but act independently of the cell wall integrity pathway. Cruz S, et al. Microbiologyopen, 2013 Oct. PMID 23907979, Free PMC Article
  5. Cooperation between the septins and the actomyosin ring and role of a cell-integrity pathway during cell division in fission yeast. Wu JQ, et al. Genetics, 2010 Nov. PMID 20739711, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rgf1p and Rgf2p are alternative guanine nucleotide exchange factors with an essential overlapping function in Rho1p activation during vegetative growth.
    Title: Fission yeast rgf2p is a rho1p guanine nucleotide exchange factor required for spore wall maturation and for the maintenance of cell integrity in the absence of rgf1p.
  2. Rgf2 are involved in formation of cell wall and septum.
    Title: Rho1-GEFs Rgf1 and Rgf2 are involved in formation of cell wall and septum, while Rgf3 is involved in cytokinesis in fission yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity EXP
Inferred from Experiment
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in fungal-type cell wall biogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of regulation of ascospore wall (1->3)-beta-D-glucan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell wall organization or biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small GTPase-mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell cortex of cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cell periphery IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in division septum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in inner layer of spore wall IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RhoGEF for Rho1 Rgf2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    5080718..5085055
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020282.2 → NP_594853.1  RhoGEF for Rho1 Rgf2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594853.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9UTR5
    Conserved Domains (5) summary
    COG5422
    Location:1 → 1148
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    cd04435
    Location:204 → 285
    DEP_fRom2; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) Rom2-like proteins. Rom2-like proteins share a common domain architecture, containing, beside the RhoGEF domain, a DEP, a PH (pleckstrin homology) and a CNH ...
    pfam00621
    Location:451 → 632
    RhoGEF; RhoGEF domain
    pfam00780
    Location:831 → 1117
    CNH; CNH domain
    pfam15405
    Location:670 → 802
    PH_5; Pleckstrin homology domain
Nucleotide Protein
Heading Accession and Version

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