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gef2 RhoGEF Gef2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543168, updated on 18-Sep-2024

Summary

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Official Symbol
gef2
Official Full Name
RhoGEF Gef2
Primary source
PomBase:SPAC31A2.16
Locus tag
SPOM_SPAC31A2.16
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See gef2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003424.3 (419942..423991)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene arrestin/PY protein 1 Neighboring gene SNARE protein Sft1 Neighboring gene WD repeat-containing protein Neighboring gene ncRNA Neighboring gene Ctf18 RFC-like complex subunit Dcc1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene proteasome core particle subunit alpha 3 Neighboring gene splicing-associated factor Dre4 Neighboring gene ncRNA Neighboring gene nuclear membrane protein Tht1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanistic insights into the anchorage of the contractile ring by anillin and Mid1. Sun L, et al. Dev Cell, 2015 May 26. PMID 25959226, Free PMC Article
  2. Fission yeast type 2 node proteins Blt1p and Gef2p cooperate to ensure timely completion of cytokinesis. Kwon L, et al. BMC Mol Cell Biol, 2019 Jan 24. PMID 31041892, Free PMC Article
  3. Blt1 and Mid1 provide overlapping membrane anchors to position the division plane in fission yeast. Guzman-Vendrell M, et al. Mol Cell Biol, 2013 Jan. PMID 23149940, Free PMC Article
  4. NDR Kinase Sid2 Drives Anillin-like Mid1 from the Membrane to Promote Cytokinesis and Medial Division Site Placement. Willet AH, et al. Curr Biol, 2019 Mar 18. PMID 30853434, Free PMC Article
  5. Fission yeast Nod1 is a component of cortical nodes involved in cell size control and division site placement. Jourdain I, et al. PLoS One, 2013. PMID 23349808, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Blt1p and Gef2p work in the same pathway, rather than in parallel, to localize the NDR-family kinase Sid2p and its regulatory partner Mob1p to the division site, thereby promoting timely completion of cell division.
    Title: Fission yeast type 2 node proteins Blt1p and Gef2p cooperate to ensure timely completion of cytokinesis.
  2. our data indicate that Nod1 and Gef2 function cooperatively in a protein complex to regulate fission yeast cytokinesis.
    Title: Cooperation between Rho-GEF Gef2 and its binding partner Nod1 in the regulation of fission yeast cytokinesis.
  3. Data indicate that Nod1 and Gef2 mutually recruited each other in nodes and Nod1 also assembles Gef2 in rings.
    Title: Fission yeast Nod1 is a component of cortical nodes involved in cell size control and division site placement.
  4. Gef2 localization to cortical nodes and the contractile ring depends on its last 145 residues, and the DBL-homology domain is important for its function in cytokinesis.
    Title: Roles of putative Rho-GEF Gef2 in division-site positioning and contractile-ring function in fission yeast cytokinesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity EXP
Inferred from Experiment
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cytokinesis, division site positioning IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell division site HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in medial cortical node IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic actomyosin contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic actomyosin contractile ring, intermediate layer IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle pole body HDA PubMed 

General protein information

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Preferred Names
RhoGEF Gef2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    419942..423991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018329.3 → NP_592928.1  RhoGEF Gef2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_592928.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q09733
    Conserved Domains (2) summary
    pfam00621
    Location:237 → 423
    RhoGEF; RhoGEF domain
    pfam17114
    Location:824 → 967
    Nod1; Gef2-related medial cortical node protein Nod1
Nucleotide Protein
Heading Accession and Version

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Molecular Biology Databases
Research Materials