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spp1 DNA primase catalytic subunit Spp1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543323, updated on 14-Nov-2024

Summary

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Official Symbol
spp1
Official Full Name
DNA primase catalytic subunit Spp1
Primary source
PomBase:SPAC6B12.10c
Locus tag
SPOM_SPAC6B12.10C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
pri1
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Genomic context

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See spp1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003424.3 (2428976..2430635, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ATPase co-chaperone protein Neighboring gene ncRNA Neighboring gene ribosome assembly protein Rsa3 Neighboring gene tRNA m(1)G methyltransferase Trm10 Neighboring gene ncRNA Neighboring gene DNA replication preinitiation complex assembly protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nuclear distribution and chromatin association of DNA polymerase alpha-primase is affected by TEV protease cleavage of Cdc23 (Mcm10) in fission yeast. Yang X, et al. BMC Mol Biol, 2005 Jun 7. PMID 15941470, Free PMC Article
  2. Role of fission yeast primase catalytic subunit in the replication checkpoint. Griffiths DJ, et al. Mol Biol Cell, 2001 Jan. PMID 11160827, Free PMC Article
  3. Replication proteins influence the maintenance of telomere length and telomerase protein stability. Dahlén M, et al. Mol Cell Biol, 2003 May. PMID 12697806, Free PMC Article
  4. Essential role of Sna41/Cdc45 in loading of DNA polymerase alpha onto minichromosome maintenance proteins in fission yeast. Uchiyama M, et al. J Biol Chem, 2001 Jul 13. PMID 11344166
  5. The B-subunit of DNA polymerase alpha-primase associates with the origin recognition complex for initiation of DNA replication. Uchiyama M, et al. Mol Cell Biol, 2004 Sep. PMID 15314153, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables DNA primase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA replication, synthesis of primer IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic DNA replication initiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of alpha DNA polymerase:primase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of alpha DNA polymerase:primase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA primase catalytic subunit Spp1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2428976..2430635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019195.3 → NP_593765.1  DNA primase catalytic subunit Spp1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593765.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14215
    Conserved Domains (1) summary
    cd04860
    Location:44 → 371
    AE_Prim_S; AE_Prim_S: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. Primases are DNA-dependent RNA polymerases which synthesis the short RNA primers required for DNA replication. In addition to its ...
Nucleotide Protein
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