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tif211 translation initiation factor eIF2 alpha subunit [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543455, updated on 18-Sep-2024

Summary

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Official Symbol
tif211
Official Full Name
translation initiation factor eIF2 alpha subunit
Primary source
PomBase:SPAC3G9.09c
Locus tag
SPOM_SPAC3G9.09C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
eIF2alpha
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Genomic context

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See tif211 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (3166428..3167699)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene 5S ribosomal RNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene chromatin modification-related protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene class 1 histone deacetylase Hos2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The G1-S checkpoint in fission yeast is not a general DNA damage checkpoint. Krohn M, et al. J Cell Sci, 2008 Dec 15. PMID 19033384
  2. Phosphorylation of eukaryotic initiation factor 2 by heme-regulated inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is important for fesistance to environmental stresses. Zhan K, et al. Mol Cell Biol, 2002 Oct. PMID 12242291, Free PMC Article
  3. Crystal structure of eIF2B and insights into eIF2-eIF2B interactions. Kashiwagi K, et al. FEBS J, 2017 Mar. PMID 27627185
  4. Role of mitogen-activated protein kinase Sty1 in regulation of eukaryotic initiation factor 2alpha kinases in response to environmental stress in Schizosaccharomyces pombe. Berlanga JJ, et al. Eukaryot Cell, 2010 Jan. PMID 19880757, Free PMC Article
  5. Fission Yeast Asc1 Stabilizes the Interaction between Eukaryotic Initiation Factor 3a and Rps0A/uS2 for Protein Synthesis. Wang YT, et al. Mol Cell Biol, 2019 Oct 1. PMID 31285271, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables guanyl nucleotide exchange factor inhibitor activity TAS
Traceable Author Statement
more info
 PubMed 
enables methionyl-initiator methionine tRNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-tRNA adaptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol HDA PubMed 
part_of eukaryotic 48S preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
translation initiation factor eIF2 alpha subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    3166428..3167699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019504.3 → NP_594081.1  translation initiation factor eIF2 alpha subunit [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594081.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P56286
    Conserved Domains (3) summary
    cd04452
    Location:14 → 89
    S1_IF2_alpha; S1_IF2_alpha: The alpha subunit of translation Initiation Factor 2, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Eukaryotic and archaeal Initiation Factor 2 (e- and aIF2, respectively) ...
    PTZ00248
    Location:5 → 306
    PTZ00248; eukaryotic translation initiation factor 2 subunit 1; Provisional
    pfam07541
    Location:127 → 235
    EIF_2_alpha; Eukaryotic translation initiation factor 2 alpha subunit
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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