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grx5 mitochondrial [2Fe-2S] cluster assembly and transfer glutaredoxin Grx5 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543483, updated on 14-Nov-2024

Summary

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Official Symbol
grx5
Official Full Name
mitochondrial [2Fe-2S] cluster assembly and transfer glutaredoxin Grx5
Primary source
PomBase:SPAPB2B4.02
Locus tag
SPOM_SPAPB2B4.02
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See grx5 in Genome Data Viewer
Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003424.3 (2708048..2709309)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pig-L family GPI synthesis protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene G1/S-specific B-type cyclin Cig2 Neighboring gene P2 type calcium transporting P-type ATPase Pmc1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The fission yeast gene encoding monothiol glutaredoxin 5 is regulated by nitrosative and osmotic stresses. Kim HG, et al. Mol Cells, 2005 Aug 31. PMID 16258240
  2. Localization and function of three monothiol glutaredoxins in Schizosaccharomyces pombe. Chung WH, et al. Biochem Biophys Res Commun, 2005 May 6. PMID 15796926
  3. Formation of [4Fe-4S] clusters in the mitochondrial iron-sulfur cluster assembly machinery. Brancaccio D, et al. J Am Chem Soc, 2014 Nov 19. PMID 25347204
  4. The mitochondrial Hsp70 chaperone Ssq1 facilitates Fe/S cluster transfer from Isu1 to Grx5 by complex formation. Uzarska MA, et al. Mol Biol Cell, 2013 Jun. PMID 23615440, Free PMC Article
  5. Monothiol glutaredoxin Grx5 interacts with Fe-S scaffold proteins Isa1 and Isa2 and supports Fe-S assembly and DNA integrity in mitochondria of fission yeast. Kim KD, et al. Biochem Biophys Res Commun, 2010 Feb 12. PMID 20085751

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results indicate that Grx5 plays a central role in Fe-S assembly process through interaction with A-type Fe-S scaffold proteins Isa1 and Isa2.
    Title: Monothiol glutaredoxin Grx5 interacts with Fe-S scaffold proteins Isa1 and Isa2 and supports Fe-S assembly and DNA integrity in mitochondria of fission yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione disulfide oxidoreductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-disulfide reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in [2Fe-2S] cluster assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in [2Fe-2S] cluster assembly IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in [4Fe-4S] cluster assembly ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion HDA PubMed 
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mitochondrial [2Fe-2S] cluster assembly and transfer glutaredoxin Grx5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2708048..2709309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019318.3 → NP_593888.1  mitochondrial [2Fe-2S] cluster assembly and transfer glutaredoxin Grx5 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593888.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9HDW8
    Conserved Domains (1) summary
    COG0278
    Location:22 → 128
    GrxD; Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
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