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pop2 F-box/WD repeat protein Pop2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543514, updated on 18-Sep-2024

Summary

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Official Symbol
pop2
Official Full Name
F-box/WD repeat protein Pop2
Primary source
PomBase:SPAC4D7.03
Locus tag
SPOM_SPAC4D7.03
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
sud1
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Genomic context

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See pop2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (5354787..5357385)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene glycerophosphoryl diester phosphodiesterase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SMN complex subunit Gem6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene cis-prenyltransferase Neighboring gene translation initiation factor eIF3i

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The activity and selectivity of fission yeast Pop2p are affected by a high affinity for Zn2+ and Mn2+ in the active site. Andersen KR, et al. RNA, 2009 May. PMID 19307292, Free PMC Article
  2. sud1(+) targets cyclin-dependent kinase-phosphorylated Cdc18 and Rum1 proteins for degradation and stops unwanted diploidization in fission yeast. Jallepalli PV, et al. Proc Natl Acad Sci U S A, 1998 Jul 7. PMID 9653157, Free PMC Article
  3. Two F-box/WD-repeat proteins Pop1 and Pop2 form hetero- and homo-complexes together with cullin-1 in the fission yeast SCF (Skp1-Cullin-1-F-box) ubiquitin ligase. Kominami K, et al. Genes Cells, 1998 Nov. PMID 9990507
  4. The Protein Level of Rev1, a TLS Polymerase in Fission Yeast, Is Strictly Regulated during the Cell Cycle and after DNA Damage. Uchiyama M, et al. PLoS One, 2015. PMID 26147350, Free PMC Article
  5. F-box/WD-repeat proteins pop1p and Sud1p/Pop2p form complexes that bind and direct the proteolysis of cdc18p. Wolf DA, et al. Curr Biol, 1999 Apr 8. PMID 10209119

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like ligase-substrate adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-like ligase-substrate adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mitotic DNA replication initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of nuclear SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-box/WD repeat protein Pop2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    5354787..5357385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020387.3 → NP_594956.1  F-box/WD repeat protein Pop2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594956.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14170
    Conserved Domains (4) summary
    smart00256
    Location:242 → 282
    FBOX; A Receptor for Ubiquitination Targets
    COG2319
    Location:219 → 657
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:360 → 654
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:395 → 429
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version

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