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srs2 UvrD subfamily ATP-dependent DNA helicase [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543577, updated on 14-Nov-2024

Summary

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Official Symbol
srs2
Official Full Name
UvrD subfamily ATP-dependent DNA helicase
Primary source
PomBase:SPAC4H3.05
Locus tag
SPOM_SPAC4H3.05
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See srs2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003424.3 (3832279..3835740)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene 5S ribosomal RNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The anaphase-promoting complex/cyclosome controls repair and recombination by ubiquitylating Rhp54 in fission yeast. Trickey M, et al. Mol Cell Biol, 2008 Jun. PMID 18426916, Free PMC Article
  2. The severe slow growth of Deltasrs2 Deltarqh1 in Schizosaccharomyces pombe is suppressed by loss of recombination and checkpoint genes. Maftahi M, et al. Nucleic Acids Res, 2002 Nov 1. PMID 12409469, Free PMC Article
  3. High-throughput genetic interaction mapping in the fission yeast Schizosaccharomyces pombe. Roguev A, et al. Nat Methods, 2007 Oct. PMID 17893680
  4. Replication stress response in fission yeast differentially depends on maintaining proper levels of Srs2 helicase and Rrp1, Rrp2 DNA translocases. Baranowska G, et al. PLoS One, 2024. PMID 38905307, Free PMC Article
  5. The PCNA unloader Elg1 promotes recombination at collapsed replication forks in fission yeast. Tamang S, et al. Elife, 2019 May 31. PMID 31149897, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Replication stress response in fission yeast differentially depends on maintaining proper levels of Srs2 helicase and Rrp1, Rrp2 DNA translocases.
    Title: Replication stress response in fission yeast differentially depends on maintaining proper levels of Srs2 helicase and Rrp1, Rrp2 DNA translocases.
  2. Authors propose a model placing Rrp1 and Rrp2 functioning together with Swi5 and Srs2 in a synthesis-dependent strand annealing homologous recombination repair pathway.
    Title: Involvement of Schizosaccharomyces pombe rrp1+ and rrp2+ in the Srs2- and Swi5/Sfr1-dependent pathway in response to DNA damage and replication inhibition.
  3. Incubation of conditional srs2 rad3 ( ts ) cells at restrictive temperature led not only to a viability decrease but also to a remarkable shortening of rDNA clusters (approximately 100 copies).
    Title: Redundant roles of Srs2 helicase and replication checkpoint in survival and rDNA maintenance in Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic recombination-dependent replication fork processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postreplication repair IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in recombinational repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in recombinational repair IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in recombinational repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
UvrD subfamily ATP-dependent DNA helicase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    3832279..3835740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019762.3 → NP_594341.1  UvrD subfamily ATP-dependent DNA helicase [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594341.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q10213
    Conserved Domains (4) summary
    COG0210
    Location:9 → 642
    UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
    pfam00580
    Location:11 → 289
    UvrD-helicase; UvrD/REP helicase N-terminal domain
    pfam13538
    Location:587 → 641
    UvrD_C_2; UvrD-like helicase C-terminal domain
    cl19114
    Location:395 → 509
    RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
Nucleotide Protein
Heading Accession and Version

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