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Hcrtr1 hypocretin receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25593, updated on 27-Nov-2024

Summary

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Official Symbol
Hcrtr1provided by RGD
Official Full Name
hypocretin receptor 1provided by RGD
Primary source
RGD:2787
See related
EnsemblRapid:ENSRNOG00000013838 AllianceGenome:RGD:2787
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hctr1
Summary
Enables orexin receptor activity and peptide hormone binding activity. Involved in neuropeptide signaling pathway. Predicted to be active in plasma membrane. Orthologous to human HCRTR1 (hypocretin receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 5.7), Brain (RPKM 5.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hcrtr1 in Genome Data Viewer
Location:
5q36
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (147761392..147771846, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (142477214..142486674, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (148346029..148355404, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene collagen type XVI alpha 1 chain Neighboring gene uncharacterized LOC120102987 Neighboring gene penta-EF hand domain containing 1 Neighboring gene tubulointerstitial nephritis antigen-like 1 Neighboring gene leucine decarboxylase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hindbrain orexin 1 receptors influence palatable food intake, operant responding for food, and food-conditioned place preference in rats. Kay K, et al. Psychopharmacology (Berl), 2014 Jan. PMID 23978908, Free PMC Article
  2. Orexin/hypocretin-1 receptor antagonism reduces ethanol self-administration and reinstatement selectively in highly-motivated rats. Moorman DE, et al. Brain Res, 2017 Jan 1. PMID 27771284, Free PMC Article
  3. Role of the orexin (hypocretin) system in contextual fear conditioning in rats. Wang H, et al. Behav Brain Res, 2017 Jan 1. PMID 27575948
  4. Role of dorsal vagal motor nucleus orexin-receptor-1 in glycemic responses to acute versus repeated insulin administration. Paranjape S, et al. Neuropeptides, 2007 Apr. PMID 17276508
  5. Cultured rat calvarial osteoblast-like cells are provided with orexin type 1 receptors. Ziolkowska A, et al. Int J Mol Med, 2007 Dec. PMID 17982683

See all (106) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hypocretin-1/Hypocretin Receptor 1 Regulates Neuroplasticity and Cognitive Function through Hippocampal Lactate Homeostasis in Depressed Model.
    Title: Hypocretin-1/Hypocretin Receptor 1 Regulates Neuroplasticity and Cognitive Function through Hippocampal Lactate Homeostasis in Depressed Model.
  2. A high-fat diet induced depression-like phenotype via hypocretin-HCRTR1 mediated inflammation activation.
    Title: A high-fat diet induced depression-like phenotype via hypocretin-HCRTR1 mediated inflammation activation.
  3. The Role of Orexin-1 Receptors Within the Hippocampal CA1 Area in the Extinction and Reinstatement of Methamphetamine-Seeking Behaviors.
    Title: The Role of Orexin-1 Receptors Within the Hippocampal CA1 Area in the Extinction and Reinstatement of Methamphetamine-Seeking Behaviors.
  4. Blockade of the orexin 1-receptors and 'cocaine- and amphetamine-regulated transcript' in the nucleus accumbens shell alters impulse control in rats.
    Title: Blockade of the orexin 1-receptors and 'cocaine- and amphetamine-regulated transcript' in the nucleus accumbens shell alters impulse control in rats.
  5. Distinct roles for orexin-1 and orexin-2 receptors in the dentate gyrus of the hippocampus in the methamphetamine-seeking behavior in the rats.
    Title: Distinct roles for orexin-1 and orexin-2 receptors in the dentate gyrus of the hippocampus in the methamphetamine-seeking behavior in the rats.
  6. Disruption of 5-hydroxytryptamine 1A receptor and orexin receptor 1 heterodimer formation affects novel G protein-dependent signaling pathways and has antidepressant effects in vivo.
    Title: Disruption of 5-hydroxytryptamine 1A receptor and orexin receptor 1 heterodimer formation affects novel G protein-dependent signaling pathways and has antidepressant effects in vivo.
  7. Orexin receptors in the CA1 region of hippocampus modulate the stress-induced antinociceptive responses in an animal model of persistent inflammatory pain.
    Title: Orexin receptors in the CA1 region of hippocampus modulate the stress-induced antinociceptive responses in an animal model of persistent inflammatory pain.
  8. Orexin-A protects against cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through OX1R-mediated MAPK/ERK/mTOR pathway.
    Title: Orexin-A protects against cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through OX1R-mediated MAPK/ERK/mTOR pathway.
  9. [Increase in the level of orexin receptor 1 (OX1R) mRNA in the brain structures of rats prone to impulsivity in behavior].", trans "Povyshenie urovnia mRNK retseptora oreksina pervogo tipa (OX1R) v strukturakh golovnogo mozga u krys, sklonnykh k impul'sivnosti v povedenii.
    Title: [Increase in the level of orexin receptor 1 (OX1R) mRNA in the brain structures of rats prone to impulsivity in behavior].
  10. Activation orexin 1 receptors in the ventrolateral periaqueductal gray matter attenuate nitroglycerin-induced migraine attacks and calcitonin gene related peptide up-regulation in trigeminal nucleus caudalis of rats.
    Title: Activation orexin 1 receptors in the ventrolateral periaqueductal gray matter attenuate nitroglycerin-induced migraine attacks and calcitonin gene related peptide up-regulation in trigeminal nucleus caudalis of rats.
Submit: New GeneRIF Correction See all GeneRIFs (96)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables orexin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables orexin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables orexin receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables peptide hormone binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in feeding behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuropeptide signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
orexin/Hypocretin receptor type 1
Names
hypocretin (orexin) receptor 1
hypocretin receptor type 1
orexin receptor type 1
ox-1-R
ox1-R
ox1r

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013064.2 → NP_037196.1  orexin/Hypocretin receptor type 1

    See identical proteins and their annotated locations for NP_037196.1

    Status: VALIDATED

    Source sequence(s)
    AF041244, FN803424, JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P56718
    UniProtKB/TrEMBL
    A6ISN2
    Related
    ENSRNOP00000018674.3, ENSRNOT00000018674.8
    Conserved Domains (1) summary
    cd15208
    Location:47 → 369
    7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    147761392..147771846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109321.2 → XP_038965249.1  orexin/Hypocretin receptor type 1 isoform X1

    UniProtKB/Swiss-Prot
    P56718
    UniProtKB/TrEMBL
    A6ISN2
    Conserved Domains (1) summary
    cd15208
    Location:47 → 369
    7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56718.1 GenPept UniProtKB/Swiss-Prot:P56718

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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