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Cd6 Cd6 molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 25752, updated on 4-Jan-2025

Summary

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Symbol
Cd6provided by RGD
Full Name
Cd6 moleculeprovided by RGD
Primary source
RGD:2312
See related
EnsemblRapid:ENSRNOG00000020884 AllianceGenome:RGD:2312
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
OX52
Summary
Enables protein kinase binding activity. Involved in positive regulation of protein phosphorylation. Located in cell surface. Orthologous to human CD6 (CD6 molecule). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 500.0) and Spleen (RPKM 74.2) See more
Orthologs
human mouse all
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Genomic context

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See Cd6 in Genome Data Viewer
Location:
1q43
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (216867767..216906642, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (207442873..207481703, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (226848399..226887259, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene Cd5 molecule Neighboring gene uncharacterized LOC120099989 Neighboring gene transfer RNA alanine (anticodon AGC) 22 Neighboring gene solute carrier family 15 member 3 Neighboring gene transmembrane protein 132A Neighboring gene transmembrane protein 109

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CD6 attenuates early and late signaling events, setting thresholds for T-cell activation. Oliveira MI, et al. Eur J Immunol, 2012 Jan. PMID 21956609, Free PMC Article
  2. CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock. Sarrias MR, et al. Proc Natl Acad Sci U S A, 2007 Jul 10. PMID 17601777, Free PMC Article
  3. Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse. Castro MA, et al. J Immunol, 2007 Apr 1. PMID 17371992
  4. OX52 is the rat homologue of CD6: evidence for an effector function in the regulation of CD5 phosphorylation. Castro MA, et al. J Leukoc Biol, 2003 Jan. PMID 12525577
  5. Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction. Chappell PE, et al. Structure, 2015 Aug 4. PMID 26146185, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC108551

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lipopolysaccharide binding ISO
Inferred from Sequence Orthology
more info
  
enables lipoteichoic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in acute inflammatory response to antigenic stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
involved_in immunological synapse formation ISO
Inferred from Sequence Orthology
more info
  
involved_in lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of T cell receptor complex ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
T-cell differentiation antigen CD6
Names
CD6 antigen, Tp120
T-cell differentiation antigen CD6-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175577.3 → NP_783167.2  T-cell differentiation antigen CD6 precursor

    See identical proteins and their annotated locations for NP_783167.2

    Status: VALIDATED

    Source sequence(s)
    AF488727, BC089767, CO559874
    UniProtKB/TrEMBL
    A6I060, G3V8U0, Q812A4
    Conserved Domains (2) summary
    smart00202
    Location:160 → 259
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:165 → 259
    SRCR; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    216867767..216906642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282334.1 → XP_063138404.1  T-cell differentiation antigen CD6 isoform X7

  2. XM_008760218.4 → XP_008758440.1  T-cell differentiation antigen CD6 isoform X2

    UniProtKB/TrEMBL
    Q812A4
    Conserved Domains (2) summary
    smart00202
    Location:160 → 259
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:165 → 259
    SRCR; Scavenger receptor cysteine-rich domain

  3. XM_006231021.5 → XP_006231083.1  T-cell differentiation antigen CD6 isoform X1

    UniProtKB/TrEMBL
    Q812A4
    Related
    ENSRNOP00000028347.4, ENSRNOT00000028347.5
    Conserved Domains (2) summary
    smart00202
    Location:160 → 259
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:165 → 259
    SRCR; Scavenger receptor cysteine-rich domain

  4. XM_039102303.2 → XP_038958231.1  T-cell differentiation antigen CD6 isoform X4

    UniProtKB/TrEMBL
    Q812A4
    Conserved Domains (1) summary
    smart00202
    Location:160 → 259
    SR; Scavenger receptor Cys-rich

  5. XM_017588836.3 → XP_017444325.1  T-cell differentiation antigen CD6 isoform X3

    UniProtKB/TrEMBL
    Q812A4

  6. XM_063282341.1 → XP_063138411.1  T-cell differentiation antigen CD6 isoform X8

  7. XM_063282324.1 → XP_063138394.1  T-cell differentiation antigen CD6 isoform X6

    UniProtKB/TrEMBL
    Q812A4

  8. XM_008760219.4 → XP_008758441.1  T-cell differentiation antigen CD6 isoform X5

    UniProtKB/TrEMBL
    Q812A4
    Conserved Domains (2) summary
    smart00202
    Location:160 → 259
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:165 → 259
    SRCR; Scavenger receptor cysteine-rich domain

  9. XM_039102307.2 → XP_038958235.1  T-cell differentiation antigen CD6 isoform X9

    Conserved Domains (1) summary
    smart00202
    Location:5 → 85
    SR; Scavenger receptor Cys-rich
Nucleotide Protein Strain
Heading Accession and Version

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