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GSTT4 glutathione S-transferase theta 4 [ Homo sapiens (human) ]

Gene ID: 25774, updated on 27-Nov-2024

Summary

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Official Symbol
GSTT4provided by HGNC
Official Full Name
glutathione S-transferase theta 4provided by HGNC
Primary source
HGNC:HGNC:26930
See related
Ensembl:ENSG00000276950 AllianceGenome:HGNC:26930
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GSTTP1; HS322B1A
Summary
Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis (RPKM 4.0) See more
Orthologs
mouse all
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Genomic context

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See GSTT4 in Genome Data Viewer
Location:
22q11.23
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (23989115..24005453, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (24405779..24412527, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24340595..24347350, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene D-dopachrome tautomerase like Neighboring gene D-dopachrome tautomerase Neighboring gene glutathione S-transferase theta 2 (gene/pseudogene) Neighboring gene uncharacterized LOC105372959 Neighboring gene calcineurin binding protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24487229-24487730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24487731-24488230 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:24527017-24527518 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24540118-24540852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24540853-24541588 Neighboring gene Sharpr-MPRA regulatory region 1007 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18761 Neighboring gene skeletal muscle cis-regulatory module in CABIN1 intron Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24571075-24571934

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genetic polymorphism of glutathione S-transferase P1 gene and lung cancer risk. To-Figueras J, et al. Cancer Causes Control, 1999 Feb. PMID 10334644
  2. The DNA sequence of human chromosome 22. Dunham I, et al. Nature, 1999 Dec 2. PMID 10591208
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

Homology

Clone Names

  • MGC119755, MGC119756

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glutathione S-transferase theta-4
Names
GST class-theta-4
glutathione S-transferase theta pseudogene 1
NP_001345593.1
XP_024307967.1
XP_024307968.1
XP_024307970.1
XP_054181452.1
XP_054181453.1
XP_054181454.1
XP_054185427.1
XP_054185428.1
XP_054185429.1
XP_054185430.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358664.2 → NP_001345593.1  glutathione S-transferase theta-4

    Status: VALIDATED

    Source sequence(s)
    AC253536
    Consensus CDS
    CCDS87011.1
    UniProtKB/Swiss-Prot
    A0A1W2PR19
    UniProtKB/TrEMBL
    A0A1W2PQM5
    Related
    ENSP00000492273.1, ENST00000621179.6
    Conserved Domains (2) summary
    cd03183
    Location:91 → 217
    GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
    cl00388
    Location:3 → 78
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RNA

  1. NR_003081.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC253536
    Related
    ENST00000611600.4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    23989115..24005453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452202.2 → XP_024307970.1  glutathione S-transferase theta-4 isoform X3

    Conserved Domains (2) summary
    cl00388
    Location:7 → 81
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    cl02776
    Location:100 → 157
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

  2. XM_024452199.2 → XP_024307967.1  glutathione S-transferase theta-4 isoform X1

    Conserved Domains (2) summary
    cl00388
    Location:7 → 81
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    cl02776
    Location:100 → 198
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

  3. XM_024452200.2 → XP_024307968.1  glutathione S-transferase theta-4 isoform X2

    Conserved Domains (2) summary
    cl00388
    Location:32 → 71
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    cl02776
    Location:90 → 188
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187633.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    224697..241525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329455.1 → XP_054185430.1  glutathione S-transferase theta-4 isoform X6

  2. XM_054329452.1 → XP_054185427.1  glutathione S-transferase theta-4 isoform X4

  3. XM_054329454.1 → XP_054185429.1  glutathione S-transferase theta-4 isoform X5

  4. XM_054329453.1 → XP_054185428.1  glutathione S-transferase theta-4 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    24405779..24412527 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325477.1 → XP_054181452.1  glutathione S-transferase theta-4 isoform X7

  2. XM_054325479.1 → XP_054181454.1  glutathione S-transferase theta-4 isoform X8

  3. XM_054325478.1 → XP_054181453.1  glutathione S-transferase theta-4 isoform X8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001039498.1: Suppressed sequence

    Description
    NM_001039498.1: This RefSeq was permanently suppressed because we now believe this locus is a pseudogene rather than a protein-coding gene.

  2. NM_001040638.1: Suppressed sequence

    Description
    NM_001040638.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.

  3. NM_015371.1: Suppressed sequence

    Description
    NM_015371.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidiate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A1W2PR19.1 GenPept UniProtKB/Swiss-Prot:A0A1W2PR19

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Chemical Information
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