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GAGE6 G antigen 6 [ Homo sapiens (human) ]

Gene ID: 2578, updated on 27-Nov-2024

Summary

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Official Symbol
GAGE6provided by HGNC
Official Full Name
G antigen 6provided by HGNC
Primary source
HGNC:HGNC:4103
See related
MIM:300599; AllianceGenome:HGNC:4103
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT4.6
Summary
This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YYWPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. [provided by RefSeq, Jul 2008]
Annotation information
not in current annotation release
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Genomic context

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See GAGE6 in Genome Data Viewer
Location:
Xp11.4-p11.2

Bibliography

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Related articles in PubMed

  1. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. Van den Eynde B, et al. J Exp Med, 1995 Sep 1. PMID 7544395, Free PMC Article
  2. Isolation and characterization of PAGE-1 and GAGE-7. New genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens. Chen ME, et al. J Biol Chem, 1998 Jul 10. PMID 9651357
  3. Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. De Backer O, et al. Cancer Res, 1999 Jul 1. PMID 10397259
  4. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. Gjerstorff MF, et al. Tissue Antigens, 2008 Mar. PMID 18179644
  5. A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220. Hou P, et al. Cancer Res, 2017 Aug 15. PMID 28625976, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

General protein information

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Preferred Names
G antigen 6
Names
GAGE-6
cancer/testis antigen 4.6
cancer/testis antigen family 4, member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001476.1 → NP_001467.1  G antigen 6

    See identical proteins and their annotated locations for NP_001467.1

    Status: REVIEWED

    Source sequence(s)
    U19147
    UniProtKB/Swiss-Prot
    Q13070
    UniProtKB/TrEMBL
    B7ZVY3
    Conserved Domains (1) summary
    pfam05831
    Location:1 → 114
    GAGE; GAGE protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13070.1 GenPept UniProtKB/Swiss-Prot:Q13070

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials