ZDHHC5 zinc finger DHHC-type palmitoyltransferase 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZDHHC5provided by HGNC
Official Full Name: zinc finger DHHC-type palmitoyltransferase 5provided by HGNC
Primary source: HGNC:HGNC:18472
See related: Ensembl:ENSG00000156599 MIM:614586; AllianceGenome:HGNC:18472
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DHHC5; ZNF375
Summary: Enables protein-cysteine S-palmitoyltransferase activity. Involved in positive regulation of defense response; positive regulation of protein localization to plasma membrane; and protein localization to plasma membrane. Acts upstream of or within protein palmitoylation. Located in nucleoplasm; phagocytic vesicle; and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in esophagus (RPKM 30.1), thyroid (RPKM 23.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q12.1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (57668114..57701182)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (57618060..57651360)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (57435586..57468654)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging.
Title: Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging.
ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation.
Title: ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation.
ZDHHC5-mediated S-palmitoylation of FAK promotes its membrane localization and epithelial-mesenchymal transition in glioma.
Title: ZDHHC5-mediated S-palmitoylation of FAK promotes its membrane localization and epithelial-mesenchymal transition in glioma.
The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike (S) protein and their effects on S protein's subcellular localization, palmitoylation and pseudovirus entry.
Title: The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike (S) protein and their effects on S protein's subcellular localization, palmitoylation and pseudovirus entry.
Regulation and function of the palmitoyl-acyltransferase ZDHHC5.
Title: Regulation and function of the palmitoyl-acyltransferase ZDHHC5.
Control of protein palmitoylation by regulating substrate recruitment to a zDHHC-protein acyltransferase.
Title: Control of protein palmitoylation by regulating substrate recruitment to a zDHHC-protein acyltransferase.
DHHC5 Mediates beta-Adrenergic Signaling in Cardiomyocytes by Targeting Galpha Proteins.
Title: DHHC5 Mediates β-Adrenergic Signaling in Cardiomyocytes by Targeting Gα Proteins.
Study findings identified six miRNAs related to gastric adenocarcinoma prognosis and suggested that downregulated miR-96-5p might induce cell apoptosis via upregulating ZDHHC5 expression in MGC-803 cells.
Title: MiR-96-5p inhibition induces cell apoptosis in gastric adenocarcinoma.
This work uncovers a novel mechanism of DHHC5 regulation by Golga7b and demonstrates a role for the DHHC5/Golga7b complex in the regulation of cell adhesion.
Title: S-acylated Golga7b stabilises DHHC5 at the plasma membrane to regulate cell adhesion.
ZDHHC5-mediated S-palmitoylation is indispensable for NOD1/2 recruitment to bacteria containing phagosomes.
Title: Palmitoylation of NOD1 and NOD2 is required for bacterial sensing.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S4384 (e-PCR)
- UniSTS:33107

A003A41 (e-PCR)
- UniSTS:32856

D11S2272E (e-PCR)
- UniSTS:76902

RH45501 (e-PCR)
- UniSTS:32924

G59234 (e-PCR)
- UniSTS:136407

D11S1777 (e-PCR), detects polymorphism
- UniSTS:70379

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-cysteine S-palmitoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of pattern recognition receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of pattern recognition receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to phagocytic vesicle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of pyroptotic inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein palmitoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein palmitoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	TAS Traceable Author Statement more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic specialization, intracellular component	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: palmitoyltransferase ZDHHC5

Names: DHHC-5; membrane-associated DHHC5 zinc finger protein; probable palmitoyltransferase ZDHHC5; zinc finger DHHC domain-containing protein 5; zinc finger DHHC-type containing 5; zinc finger protein 375; zinc finger, DHHC domain containing 5

NP_056272.2

EC 2.3.1.225

XP_011543201.1

EC 2.3.1.225

XP_011543202.1

EC 2.3.1.225

XP_011543203.1

EC 2.3.1.225

XP_047282680.1

EC 2.3.1.225

XP_054224324.1

EC 2.3.1.225

XP_054224325.1

EC 2.3.1.225

XP_054224326.1

EC 2.3.1.225

XP_054224327.1

EC 2.3.1.225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.