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Wipf3 WAS/WASL interacting protein family, member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 259242, updated on 4-Jan-2025

Summary

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Official Symbol
Wipf3provided by RGD
Official Full Name
WAS/WASL interacting protein family, member 3provided by RGD
Primary source
RGD:708559
See related
EnsemblRapid:ENSRNOG00000009571 AllianceGenome:RGD:708559
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cr16
Summary
Enables SH3 domain binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation; endosomal transport; and exocytosis. Predicted to be located in cytosol. Predicted to be part of WASH complex. Predicted to be active in early endosome; recycling endosome; and synapse. Orthologous to human WIPF3 (WAS/WASL interacting protein family member 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 40.0), Muscle (RPKM 19.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wipf3 in Genome Data Viewer
Location:
4q24
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (84880403..84960250)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (83550075..83629929)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (84596305..84676775)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 beta 2, pseudogene 1 Neighboring gene proline rich 15 Neighboring gene secernin 1 Neighboring gene uncharacterized LOC102553885 Neighboring gene FKBP prolyl isomerase 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CR16, a novel proline-rich protein expressed in rat brain neurons, binds to SH3 domains and is a MAP kinase substrate. Weiler MC, et al. J Mol Neurosci, 1996 Fall. PMID 8906616
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH3 domain binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables alpha-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-tubulin binding IEA
Inferred from Electronic Annotation
more info
  
enables gamma-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Arp2/3 complex-mediated actin nucleation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of WASH complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of WASH complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
WAS/WASL-interacting protein family member 3
Names
SH3 domain binding protein CR16
corticosteroids and regional expression protein 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398730.1 → NP_001385659.1  WAS/WASL-interacting protein family member 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q62775, Q9Z0G8
    UniProtKB/TrEMBL
    A0A8L2UNK9
    Related
    ENSRNOP00000111347.1, ENSRNOT00000135514.1
    Conserved Domains (1) summary
    cd22077
    Location:42 → 71
    WH2_WAS_WASL-2_3; Wiskott Aldrich syndrome homology region 2 (WH2 motif) in WAS/WASL-interacting protein (WIP) family members 2 and 3

  2. NM_147211.3 → NP_671744.1  WAS/WASL-interacting protein family member 3 isoform 2

    See identical proteins and their annotated locations for NP_671744.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8L2UNK9
    Related
    ENSRNOP00000012755.5, ENSRNOT00000012755.8
    Conserved Domains (1) summary
    pfam02205
    Location:45 → 69
    WH2; WH2 motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    84880403..84960250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107139.2 → XP_038963067.1  WAS/WASL-interacting protein family member 3 isoform X1

    UniProtKB/TrEMBL
    A0A8L2UNK9
    Related
    ENSRNOP00000064597.4, ENSRNOT00000074054.4
    Conserved Domains (1) summary
    cd22077
    Location:42 → 71
    WH2_WAS_WASL-2_3; Wiskott Aldrich syndrome homology region 2 (WH2 motif) in WAS/WASL-interacting protein (WIP) family members 2 and 3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z0G8.1 GenPept UniProtKB/Swiss-Prot:Q9Z0G8

Gene LinkOut

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