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Nmt1 N-myristoyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 259274, updated on 27-Nov-2024

Summary

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Symbol
Nmt1provided by RGD
Full Name
N-myristoyltransferase 1provided by RGD
Primary source
RGD:628642
See related
EnsemblRapid:ENSRNOG00000002989 AllianceGenome:RGD:628642
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables myristoyltransferase activity. Predicted to be involved in N-terminal peptidyl-glycine N-myristoylation; cellular ketone metabolic process; and protein localization to membrane. Predicted to act upstream of or within N-terminal protein myristoylation and in utero embryonic development. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol. Orthologous to human NMT1 (N-myristoyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 312.3), Thymus (RPKM 249.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nmt1 in Genome Data Viewer
Location:
10q32.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (88488918..88525496)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (87988826..88025405)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (91126689..91160721)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L22 like 4 Neighboring gene complement C1q like 1 Neighboring gene dephospho-CoA kinase domain containing Neighboring gene phospholipase C, delta 3 Neighboring gene acyl-CoA binding domain containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Altered expression and localization of N-myristoyltransferase in experimentally induced rat model of ischemia-reperfusion. Rajala RV, et al. J Cell Biochem, 2002. PMID 12210757
  2. Expression and activities of N-myristoyltransferase and calcineurin in normal and inflamed lungs. Charavaryamath C, et al. Exp Lung Res, 2009 Nov. PMID 19916857
  3. N-myristoyltransferase: a potential novel diagnostic marker for colon cancer. Shrivastav A, et al. J Transl Med, 2007 Nov 16. PMID 18021392, Free PMC Article
  4. Identification and characterization of recombinant and native rat myristoyl-CoA: protein N-myristoyltransferases. Rioux V, et al. Mol Cell Biochem, 2006 Jun. PMID 16538398
  5. Human N-myristoyltransferase amino-terminal domain involved in targeting the enzyme to the ribosomal subcellular fraction. Glover CJ, et al. J Biol Chem, 1997 Nov 7. PMID 9353336

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cell-specific increase expression of myristoyltransferase and calcineurin in lung epithelium and endothelium
    Title: Expression and activities of N-myristoyltransferase and calcineurin in normal and inflamed lungs.
  2. N-myristoyltransferase may have a role in progression of colonic neoplasms
    Title: N-myristoyltransferase: a potential novel diagnostic marker for colon cancer.
  3. NMT1 protein exhibited functional myristoyltransferase activity.
    Title: Identification and characterization of recombinant and native rat myristoyl-CoA: protein N-myristoyltransferases.
  4. Altered expression and localization of N-myristoyltransferase in experimentally induced rat model of ischemia-reperfusion.
    Title: Altered expression and localization of N-myristoyltransferase in experimentally induced rat model of ischemia-reperfusion.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glycylpeptide N-tetradecanoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycylpeptide N-tetradecanoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycylpeptide N-tetradecanoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycylpeptide N-tetradecanoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables myristoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables myristoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidyl-lysine N6-myristoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-lysine N6-myristoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidyl-lysine N6-myristoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in N-terminal peptidyl-glycine N-myristoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in N-terminal peptidyl-glycine N-myristoylation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within N-terminal protein myristoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in ketone metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ketone metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glycylpeptide N-tetradecanoyltransferase 1
Names
NMT 1
myristoyl-CoA:protein N-myristoyltransferase 1
peptide N-myristoyltransferase 1
type I N-myristoyltransferase
NP_683689.1
XP_038941229.1
XP_038941230.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_148891.2 → NP_683689.1  glycylpeptide N-tetradecanoyltransferase 1

    See identical proteins and their annotated locations for NP_683689.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097277
    UniProtKB/Swiss-Prot
    Q8K1Q0
    UniProtKB/TrEMBL
    A0A8I6ATE4, A6HJP2
    Related
    ENSRNOP00000004046.5, ENSRNOT00000004046.8
    Conserved Domains (3) summary
    COG5092
    Location:86 → 484
    NMT1; N-myristoyl transferase [Lipid metabolism]
    pfam01233
    Location:137 → 291
    NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
    pfam02799
    Location:308 → 483
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    88488918..88525496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085301.2 → XP_038941229.1  glycylpeptide N-tetradecanoyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ATE4
    Conserved Domains (1) summary
    COG5092
    Location:16 → 414
    NMT1; N-myristoyl transferase [Lipid metabolism]

  2. XM_039085302.2 → XP_038941230.1  glycylpeptide N-tetradecanoyltransferase 1 isoform X2

    Conserved Domains (2) summary
    pfam01233
    Location:1 → 105
    NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
    pfam02799
    Location:122 → 308
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1Q0.1 GenPept UniProtKB/Swiss-Prot:Q8K1Q0

Gene LinkOut

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