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Klk8 kallikrein related-peptidase 8 [ Mus musculus (house mouse) ]

Gene ID: 259277, updated on 27-Nov-2024

Summary

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Official Symbol
Klk8provided by MGI
Official Full Name
kallikrein related-peptidase 8provided by MGI
Primary source
MGI:MGI:1343327
See related
Ensembl:ENSMUSG00000064023 AllianceGenome:MGI:1343327
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NP; BSP1; Nrpn; Prss19
Summary
This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. Mice lacking the encoded protein exhibit impaired long-term potentiation and increased anxiety, as well as a hyperkeratosis phenotype. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, May 2016]
Expression
Broad expression in stomach adult (RPKM 16.0), thymus adult (RPKM 5.0) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Klk8 in Genome Data Viewer
Location:
7 B3; 7 28.26 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43447001..43453250)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43797532..43803826)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene kallikrein related-peptidase 10 Neighboring gene kallikrein related-peptidase 9 Neighboring gene kallikrein related-peptidase 7 (chymotryptic, stratum corneum) Neighboring gene kallikrein related-peptidase 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Involvement of neuropsin in the pathogenesis of experimental autoimmune encephalomyelitis. Terayama R, et al. Glia, 2005 Nov 1. PMID 15920728
  2. Neuropsin (KLK8)-dependent and -independent synaptic tagging in the Schaffer-collateral pathway of mouse hippocampus. Ishikawa Y, et al. J Neurosci, 2008 Jan 23. PMID 18216192, Free PMC Article
  3. Increased anxiety-like behavior in neuropsin (kallikrein-related peptidase 8) gene-deficient mice. Horii Y, et al. Behav Neurosci, 2008 Jun. PMID 18513120
  4. Assignment of the neuropsin gene (Prss19) to mouse chromosome band 7B4 by in situ hybridization. Yoshida S, et al. Cytogenet Cell Genet, 2000. PMID 10773678
  5. Klk8, a multifunctional protease in the brain and skin: analysis of knockout mice. Yoshida S. Biol Chem, 2010 Apr. PMID 20180635

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1.
    Title: Upregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1.
  2. Genetic knockdown of Klk8 has sex-specific multi-targeted therapeutic effects on Alzheimer's pathology in mice.
    Title: Genetic knockdown of Klk8 has sex-specific multi-targeted therapeutic effects on Alzheimer's pathology in mice.
  3. A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis.
    Title: A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis.
  4. Klk8 knockout mice (NRG1-deactivated mice) exhibited normal social approach but impaired social discrimination
    Title: Impaired social discrimination behavior despite normal social approach by kallikrein-related peptidase 8 knockout mouse.
  5. KLK8 deficiency in mouse hippocampus reduced L1CAM cleavage and MAP2c levels and caused profound loss of dendrites. Disruption of dendrite growth impaired novel object recognition memory in KLK8 compromised mice possibly via inhibition of PKA/CREB signaling.
    Title: A serine protease KLK8 emerges as a regulator of regulators in memory: Microtubule protein dependent neuronal morphology and PKA-CREB signaling.
  6. Letter: NGF-p75 and neuropsin/KLK8 pathways may cooperate in regulation of epidermal homeostasis in inflamed skin.
    Title: NGF-p75 and neuropsin/KLK8 pathways stimulate each other to cause hyperkeratosis and acanthosis in inflamed skin.
  7. Klk8 is involved in the proliferation and migration of keratinocytes through Klk6 in the early stages of wound healing, and possibly in keratinocyte differentiation associated with the upregulation of PAR2 in the late stages of wound healing.
    Title: Kallikrein-related peptidase 8-dependent skin wound healing is associated with upregulation of kallikrein-related peptidase 6 and PAR2.
  8. KLK8 is involved in synaptic tagging during LTP at basal and apical dendritic inputs.
    Title: Diversity of neuropsin (KLK8)-dependent synaptic associativity in the hippocampal pyramidal neuron.
  9. the serine protease neuropsin is critical for stress-related plasticity in the amygdala by regulating the dynamics of the EphB2-NMDA-receptor interaction, the expression of Fkbp5 and anxiety-like behaviour
    Title: Neuropsin cleaves EphB2 in the amygdala to control anxiety.
  10. Klk8 might thus be involved in tissue development and rearrangement.
    Title: Klk8, a multifunctional protease in the brain and skin: analysis of knockout mice.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to wounding IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within synapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of serine protease inhibitor complex IEA
Inferred from Electronic Annotation
more info
  
part_of serine protease inhibitor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kallikrein-8
Names
Brain Serine protease 1
protease, serine, 19 (neuropsin)
NP_001311327.1
NP_032966.1
XP_030098463.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324398.1 → NP_001311327.1  kallikrein-8 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AB074296, AC151989, EH106421
    Consensus CDS
    CCDS21182.1
    UniProtKB/Swiss-Prot
    Q61955, Q8K5D7
    UniProtKB/TrEMBL
    A0A0B6VRH9, A0A0U1RNI7
    Related
    ENSMUSP00000145580.2, ENSMUST00000205537.2
    Conserved Domains (1) summary
    smart00020
    Location:32 → 252
    Tryp_SPc; Trypsin-like serine protease

  2. NM_008940.3 → NP_032966.1  kallikrein-8 preproprotein

    See identical proteins and their annotated locations for NP_032966.1

    Status: REVIEWED

    Source sequence(s)
    AB074296, AC151989, EH106421
    Consensus CDS
    CCDS21182.1
    UniProtKB/Swiss-Prot
    Q61955, Q8K5D7
    UniProtKB/TrEMBL
    A0A0B6VRH9, A0A0U1RNI7
    Related
    ENSMUSP00000082588.3, ENSMUST00000085461.4
    Conserved Domains (1) summary
    smart00020
    Location:32 → 252
    Tryp_SPc; Trypsin-like serine protease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    43447001..43453250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242603.2 → XP_030098463.1  kallikrein-8 isoform X1

    Conserved Domains (1) summary
    smart00020
    Location:1 → 131
    Tryp_SPc; Trypsin-like serine protease
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61955.1 GenPept UniProtKB/Swiss-Prot:Q61955

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