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hhat-1 Protein-cysteine N-palmitoyltransferase HHAT [ Caenorhabditis elegans ]

Gene ID: 259478, updated on 9-Dec-2024

Summary

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Official Symbol
hhat-1
Official Full Name
Protein-cysteine N-palmitoyltransferase HHAT
Primary source
WormBase:WBGene00013852
Locus tag
CELE_ZC101.3
See related
AllianceGenome:WB:WBGene00013852
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable palmitoyltransferase activity. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in chondrodysplasia-pseudohermaphroditism syndrome. Orthologous to several human genes including HHAT (hedgehog acyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hhat-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (14678457..14681148)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serpentine receptor class epsilon-13 Neighboring gene ncRNA Neighboring gene Aamy domain-containing protein;Glycosyl hydrolase family 13 catalytic domain-containing protein Neighboring gene ncRNA Neighboring gene Basement membrane proteoglycan;Basement membrane-specific heparan sulfate proteoglycan core protein;Ig-like domain-containing protein Neighboring gene DUF148 domain-containing protein;Phage protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptomic Analysis Reveals JAK2/MPL-Independent Effects of Calreticulin Mutations in a C. elegans Model. Guijarro-Hernández A, et al. Cells, 2023 Jan 2. PMID 36611979, Free PMC Article
  2. Homologs of the Hh signalling network in C. elegans. Bürglin TR, et al. WormBook, 2006 Jan 28. PMID 18050469, Free PMC Article
  3. Meta-Analysis of Caenorhabditis elegans Transcriptomics Implicates Hedgehog-Like Signaling in Host-Microbe Interactions. Zárate-Potes A, et al. Front Microbiol, 2022. PMID 35620104, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein-cysteine N-palmitoyltransferase HHAT
NP_001022489.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    14678457..14681148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027318.6 → NP_001022489.1  Protein-cysteine N-palmitoyltransferase HHAT [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022489.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFT7
    Conserved Domains (2) summary
    pfam16782
    Location:195 → 249
    SIL1; Nucleotide exchange factor SIL1
    cl00738
    Location:227 → 457
    MBOAT; MBOAT, membrane-bound O-acyltransferase family
Nucleotide Protein
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