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Y50D7A.10 ADF-H domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 259487, updated on 9-Dec-2024

Summary

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Official Symbol
Y50D7A.10
Official Full Name
ADF-H domain-containing protein
Primary source
WormBase:WBGene00021758
Locus tag
CELE_Y50D7A.10
See related
AllianceGenome:WB:WBGene00021758
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable Arp2/3 complex binding activity. Predicted to be involved in actin filament debranching and negative regulation of Arp2/3 complex-mediated actin nucleation. Predicted to be active in cortical actin cytoskeleton. Orthologous to human GMFB (glia maturation factor beta) and GMFG (glia maturation factor gamma). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See Y50D7A.10 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (315460..321716)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene 30S ribosomal protein S15;Peptidase metallopeptidase domain-containing protein Neighboring gene DUF295 domain-containing protein;F-box domain-containing protein Neighboring gene ncRNA Neighboring gene Alkyldihydroxyacetonephosphate synthase Neighboring gene PDZ domain-containing protein Neighboring gene BZIP domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables Arp2/3 complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Arp2/3 complex binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament debranching IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament debranching IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cellular component biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cellular component organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ADF-H domain-containing protein
NP_871652.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    315460..321716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_181923.6 → NP_871652.2  ADF-H domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871652.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IAA5
    Conserved Domains (1) summary
    cd11283
    Location:9 → 130
    ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins
Nucleotide Protein
Heading Accession and Version

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