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drr-2 Serine/arginine-rich splicing factor 2 [ Caenorhabditis elegans ]

Gene ID: 259546, updated on 14-Nov-2024

Summary

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Official Symbol
drr-2
Official Full Name
Serine/arginine-rich splicing factor 2
Primary source
WormBase:WBGene00011730
Locus tag
CELE_T12D8.2
See related
AllianceGenome:WB:WBGene00011730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Part of eukaryotic 48S preinitiation complex. Is expressed in several structures, including coelomocyte; excretory canal; neurons; ventral nerve cord; and vulva. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human EIF4H (eukaryotic translation initiation factor 4H). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See drr-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (13642420..13643570, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Acyl-CoA-binding domain-containing protein 6 Neighboring gene BolA family protein Neighboring gene PHD-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. drr-2 encodes an eIF4H that acts downstream of TOR in diet-restriction-induced longevity of C. elegans. Ching TT, et al. Aging Cell, 2010 Aug. PMID 20456299, Free PMC Article
  2. Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Steinkraus KA, et al. Aging Cell, 2008 Jun. PMID 18331616, Free PMC Article
  3. Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Greer EL, et al. Aging Cell, 2009 Apr. PMID 19239417, Free PMC Article
  4. Box C/D small nucleolar ribonucleoproteins regulate mitochondrial surveillance and innate immunity. Tjahjono E, et al. PLoS Genet, 2022 Mar. PMID 35275914, Free PMC Article
  5. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. Hansen M, et al. PLoS Genet, 2005 Jul. PMID 16103914, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA strand annealing activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA strand-exchange activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosomal small subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in eukaryotic translation initiation factor 4F complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in formation of translation preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of eukaryotic 48S preinitiation complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Serine/arginine-rich splicing factor 2
NP_499818.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13642420..13643570 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067417.4 → NP_499818.1  Serine/arginine-rich splicing factor 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499818.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45781
    Conserved Domains (1) summary
    cl17169
    Location:6 → 88
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
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