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cysl-3 Cysteine synthase 3 [ Caenorhabditis elegans ]

Gene ID: 259617, updated on 4-Jan-2025

Summary

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Official Symbol
cysl-3
Official Full Name
Cysteine synthase 3
Primary source
WormBase:WBGene00019962
Locus tag
CELE_R08E5.2
See related
AllianceGenome:WB:WBGene00019962
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables cysteine synthase activity. Involved in cysteine biosynthetic process from serine. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See cysl-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (3774536..3776136, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Dauer Up-Regulated Neighboring gene Dauer Up-Regulated Neighboring gene Methyltransferase domain-containing protein Neighboring gene Methyltransferase domain-containing protein Neighboring gene Glycosyl-hydrolase family 116 catalytic region domain-containing protein;Non-lysosomal glucosylceramidase Neighboring gene Peroxidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biochemical properties of nematode O-acetylserine(thiol)lyase paralogs imply their distinct roles in hydrogen sulfide homeostasis. Vozdek R, et al. Biochim Biophys Acta, 2013 Dec. PMID 24100226
  2. Mass spectrometric proteome analysis suggests anaerobic shift in metabolism of Dauer larvae of Caenorhabditis elegans. Mádi A, et al. Biochim Biophys Acta, 2008 Nov. PMID 18620082
  3. The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin/insulin-like growth factor gene ins-33 by direct DNA binding. Hristova M, et al. Mol Cell Biol, 2005 Dec. PMID 16314527, Free PMC Article
  4. Sulfurous gases as biological messengers and toxins: comparative genetics of their metabolism in model organisms. Mathew ND, et al. J Toxicol, 2011. PMID 22131987, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the role of CYSL-3 remains unclear although it exhibits sulfhydrylase activity in vitro.
    Title: Biochemical properties of nematode O-acetylserine(thiol)lyase paralogs imply their distinct roles in hydrogen sulfide homeostasis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cysteine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cysteine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cysteine biosynthetic process from serine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cysteine biosynthetic process from serine IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cysteine biosynthetic process from serine IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Cysteine synthase 3
NP_504046.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    3774536..3776136 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_071645.7 → NP_504046.1  Cysteine synthase 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504046.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H2L0J5, O01592, Q86NC6
    Conserved Domains (2) summary
    cd01561
    Location:15 → 305
    CBS_like; CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. ...
    PLN02565
    Location:2 → 321
    PLN02565; cysteine synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O01592.1

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